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NEJM: Teclistamab in relapsed/refractory multiple myeloma

 Last Update: 2022-08-19
 Source: Internet
 Author: User

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Teclistamab is a T cell redirecting bispecific antibody that targets CD3 expressed on the surface of T cells and B cell maturation antigen expressed on the surface of myeloma cell.

This is a Phase 1-2 study enrolling patients with relapsed or refractory multiple myeloma after at least three lines of therapy, including three classes of exposure to immunomodulatory drugs, proteasome inhibitors, and anti-CD38 antibodie.

A total of 165 patients received Teclistamab, and 76% had class 3 refractory disease (median lines of prior therapy: 5 lines.

Common adverse reactions included cytokine release syndrome (71%; grade 3: 6%; no grade 4), neutropenia (79%; grade 3-4: 62%), anemia (51%; 3- Grade 4: 30%) and thrombocytopenia (40%; Grades 3-4: 22%.

In conclusion, Teclistamab produced high rates of deep and durable responses in patients with relapsed or refractory multiple myeloma exposed to three classes of drug.

Original source:

Moreau Philippe, Garfall Alfred L, van de Donk Niels WCJ et a.

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