NEJM: PRIME cells with rheumatoid arthritis attacks.
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Last Update: 2020-07-28
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Source: Internet
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Author: User
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Rheumatoid arthritis, like many inflammatory diseases, has a period of rest and deterioration (flare) but the mechanism that causes the flare is not clearRecently, researchers established a clinical technique to participate in the study of rheumatoid arthritis patients received multiple blood collection for longitudinal sequencingSamples were taken at multiple points in time during patient rheumatoid arthritis flares to compare the differences in single-cell sample sequences before and after the flaresThe study found that there was a change in the blood transcription spectrum between the onset of rheumatoid arthritis until the onset of rheumatoid arthritis: pre-inflammatory interstitial hyperplasia cells in the blood circulation of patients with rheumatoid arthritis after cell activation were also said to be significantly the cell amplification of these cells, which had a common characteristic of inflammatory slide film into fibroblasts, and the cell level sdecreasing during the cycle of the patient during the flareFlow cells and classified cell sequences confirm the presence of cells in the blood of other patients with rheumatoid arthritisGenomic analysis of patients with rheumatoid arthritis showed that cells present in the blood before the flare erupted, migrating from the blood to the sliding membrane after cell activation, led to increased symptoms
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