NEJM: New Discovery! COVID-19 infection may induce the development of new type of diabetes in patients!

14, 2020 /PRNewswire/ -- There is research evidence that COVID-19 infection may cause diabetes in healthy populations, as well as severe complications of diabetes, and a recent study published in the international journal New England Journal of Medicine, from King's College London announced the establishment of a global "registry" of new cases of diabetes in patients with COVID-19The registry is designed to understand the extent and characteristics of diabetic symptoms in patients with COVID-19, as well as the best strategies for the treatment and monitoring of affected patients during and after a pandemicPhoto Source: CC0 Public Domain's clinical observational studies to date show a two-way relationship between COVID-19 and diabetes, which, on the one hand, is directly related to the increased risk of COVID-19 severity and mortality, with studies reporting that 20%-30% of patients who die from COVID-19 have diabetes; Researchers do not yet know the molecular mechanismby by which the SARS-CoV-2 virus affects the development of diabetes in a patient's body, after previous studies have shown that ACE-2 is located not only in the body's lung tissue, but also in organs and tissues involved in glucose metabolism, such as the pancreas, small intestine, adipose tissue, liver and kidneys, and ace-2 is a special protein that binds to SARS-CoV-2 and promotes the virus's entry into human cellsThe researchers speculate that by entering the tissues, SARS-CoV-2 can cause a variety of complex glucose metabolism abnormalities, and scientists have known for years that viral infections can cause type 1 diabetes in the bodyResearcher Professor Francesco Rubino said: 'Diabetes is one of the most popular chronic diseases, and now we are aware of the inevitable conflict between the two pandemics (diabetes and COVID-19) because of the short exposure of humans to the SARS-CoV-2 virus, so they do not know the exact mechanism by which the virus affects glucose metabolism in the host body, and whether the acute form of diabetes in these patients is type 1, type 2 or a new form of diabetes.' Currently, researchers don't know the severity of new diabetes in patients with COVID-19, and whether it will persist or disappear after infection, and if so, whether COVID-19 increases an individual's risk of future diabetes, so by creating such a global registry, the researchers are calling on scientists around the world to work together to quickly share relevant clinical observations and help answer these questionsFinally, the researchers say that this global registry, which collects clinical data on a regular basis, can help researchers analyze the participants' body's insulin secretion ability, insulin tolerance and autoimmune antibody status to better understand the occurrence, natural history and optimal management of COVID-19-related diabetes, which could also provide new ideas for revealing the pathogenesis of other human diseases(BioValleyBioon.com) Original origin: Francesco Rubino, et alNew-Onset Diabetes in Covid-19, NEJM, June 12, 2020DOI: 10.1056/NEJMc2018688