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NEJM: Merck's ROR1 ADC demonstrates the potential of lymphoma treatment

 Last Update: 2021-12-01
 Source: Internet
 Author: User

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2 5 dimethoxybenzaldehyde

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The original developer of Zilovertamab vedotin was VelosBio, and the research and development code at that time was VLS-101

The clinical indication of Zilovertamab vedotin Phase I is lymphoid malignancies.

Lymphoma Leukemia

In this test, except for the acute neutropenia and cumulative neuropathy caused by Monomethyl auristatin E contained in ADC, Zilovtamab vedotin did not bring more than expected toxicity and showed anti-tumor activity

ROR1

ROR1 is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family and is a cell surface protein

child

(Source of the structure and signal transduction of ROR1 in cancer: [2])

At the same time, on November 10, 2021, the Center for Drug Evaluation undertook the clinical application of Merck R&D (China) Co.

Reference source:

[1] Wang ML, Barrientos JC, Furman RR, et al.

[2] Borcherding N, Kusner D, Liu GH, Zhang W.

[3] Balakrishnan A, Goodpaster T, Randolph-Habecker J, Hoffstrom BG, Jalikis FG, Koch LK, Berger C, Kosasih PL, Rajan A, Sommermeyer D, Porter PL, Riddell SR.

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