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NEJM: Hydrocortisone treatment started 2 weeks after birth does not significantly improve survival without moderate to severe bronchopulmonary dysplasia in premature infants

 Last Update: 2022-04-23
 Source: Internet
 Author: User

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Bronchopulmonary dysplasia is prevalent in very preterm infants, accounting for approximately 50% of surviving infants, and preterm birth, mechanical ventilation, oxygen exposure, and inflammation are important factors in bronchopulmonary dysplasia in preterm infants

We investigated the effects of hydrocortisone treatment on lung development, neurodevelopment, and survival in preterm infants with bronchopulmonary dysplasia after the second week of life

Differences in efficacy and safety endpoints between groups

In preterm infants with bronchopulmonary dysplasia , treatment with hydrocortisone from days 14 to 28 did not improve survival without moderate to severe bronchopulmonary dysplasia, nor did 2-year neurodevelopmental outcomes between groups Significant difference

In preterm infants with bronchopulmonary dysplasia, treatment with hydrocortisone starting from postnatal days 14 to 28 did not improve survival without moderate to severe bronchopulmonary dysplasia, nor did the 2-year neurodevelopmental outcomes differ significantly between groups
.
In preterm infants with bronchopulmonary dysplasia, treatment with hydrocortisone starting from postnatal days 14 to 28 did not improve survival without moderate to severe bronchopulmonary dysplasia, nor did the 2-year neurodevelopmental outcomes differ significantly between groups
.

Original Source:
Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia.

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