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NEJM: BCMA targeted CAR-T cell therapy Idecabtagene Vicleucel (Ide-cel) achieved positive results

 Last Update: 2021-03-19
 Source: Internet
 Author: User

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The Phase II KarMMa trial evaluated the efficacy and safety of CAR-T cell therapy targeted by the B cell maturation antigen (BCMA) of bluebird bio and Bristol Myers Squibb .

CAR-T immunity

The KarMMa study reached the primary endpoint of overall response rate and the key secondary endpoint of complete response rate.

The data showed that triple-exposed RRMM patients (n = 128) received ide-cel treatment to produce a deep and long-lasting response.

In the KarMMa study, ide-cel is consistent with the known toxicity of CAR-T cell therapy, regardless of the dose level.

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