NBE . . . The new anti-tumor nanodrug enables an effective combination of vascular embolism and chemotherapy.

Tumor vascular embolization therapy is a treatment method that forms thrombus in tumor blood vessels, blocks blood supply and makes tumor cells starve and necrosis due to lack of nutrition and oxygen.for most cancer patients, the drugs are targeted at the vascularized tumor.therefore, this kind of treatment has a good clinical application prospect.at present, the commonly used vascular embolic agents mainly include iodized oil, sodium alginate microspheres, polyvinyl alcohol embolization microspheres, polyvinyl alcohol modified microspheres (DC beam), etc.although they are effective in the treatment of malignant tumors with rich blood supply such as liver cancer, in most cases, they have significant stimulating effect on blood vessels, and can cause side effects such as vasospasm and aseptic endovasculitis.moreover, the mechanism of blocking blood vessels is physical blockage, which is easy to cause recanalization in a short time due to degradation of materials.in addition, they are not targeted, and release into the blood stream can easily lead to the wrong thrombus of non target organs.therefore, it is necessary to search for new safe and effective bio embolic agents.to solve this scientific problem, in March 2018, researcher Nie Guangjun, researcher Ding Baoquan and academician Zhao Yuliang of National Center for nanoscience cooperated with Professor Yan Hao of Arizona State University in nature The article published in the Journal of biotechnology has successfully constructed DNA nanorobot, a nano bioembolic agent that can be administered intravenously. Thrombin, a hemostatic drug, is loaded into the nanorobot. The precise positioning of thrombin in tumor tissue, selective induction of tumor vascular embolism and effective "starvation" of tumor are achieved.the development of DNA nanorobots working in vivo has innovated the treatment of tumor vascular embolization.at the same time, DNA nanorobot represents a new mode of human precise drug design in the future, and provides a new intelligent strategy for the treatment of cancer and other diseases.in order to further improve the cure rate of tumor with vascular embolization therapy, recently, researchers Nie Guangjun, researcher Wu Yan and academician Zhao Yuliang of the National Center for nanoscience published the article combination of tumour information therapy and chemotherapy via the co delivery of doxorubicin and thrombin encapsulated in the journal Nature biomedical engineering In tumour targeted nanoparticles, an intelligent polymer nanodrug was developed, which carried thrombin and chemotherapy drug doxorubicin (DOX) at the same time. Through the surface functionalization of nano drugs, the chemotherapeutic drugs were simultaneously diffused to tumor areas without blood supply or dependent on vascular growth, so as to kill tumor tissue to the greatest extent (Fig. 1).Figure 1. The design idea and working principle of nano drug loaded with coagulant factor thrombin and chemotherapeutic drugs. This study provides a new idea for the development of new anti-tumor vascular drugs, and has guiding significance for the scheme design of improving the clinical efficacy of embolization therapy.the co first author of this paper is researcher Li Suping and Dr. Zhang Yinlong.original link plate maker: Qi sauce