Nature's got a hammer? Scientists isolate SARS-CoV-2-related coronavirus from Malaya pangolin

2020 May 13 News /BioValleyBIOON / - The new crown to global health epidemic of pneumonia brought unprecedented challengesNovel coronavirus SARS-CoV-2 with SARS-CoV and bat coronavirus RaTG132 with high sequence homologyAlthough bats may be a variety of coronavirus host, but SARS-CoV-2 Are there other host host remains unclearrecently from South China Agricultural University College of Veterinary Medicine, the researchers College of Veterinary Medicine, South China Agricultural University, Guangzhou Zoo, Guangdong wild animal rescue center, China Agricultural University, and other units of a discovery they get separated from a Malayan pangolin in coronavirus E, M, N, and S gene, respectively and amino acid homology SARS-CoV-2 is 100%, 98.6%, 97.8% and 90.7%In particular, pangolin coronavirus S protein receptor binding domain of the SARS-CoV-2 receptor binding domain of nearly identical, the difference is only a non-critical amino acidSource: Naturerelated research recently published in Nature, an article entitled "IsolationofSARS-CoV-2-relatedcoronavirusfromMalayanpangolins"researchers found by comparative genomic analysis, SARS-CoV-2 may be derived from similar pangolin coronavirus virus and recombinant virus is similar to the coronaviruses RaTG132 the batMalayan pangolin in 25 kinds of analysis, the researchers found the body of 17 kinds of pangolin pangolin virusresearchers found infected pangolin clinical symptoms and histological changes, pangolin coronavirus antibodies in their circulation with the S protein SARS-CoV-2 can reactresearchers believe that the separation of a kind and in pangolin SARS-CoV-2 coronavirus highly correlated, suggesting they may serve as an intermediate host of the SARS-CoV-2If the wildlife trade is not effectively controlled, this newly discovered coronavirus might be a threat to public healtha (Biovalley Bioon.com) References:Xiao, K., Zhai, J., Feng, Y.etal IsolationofSARS-CoV-2-relatedcoronavirusfromMalayanpangolins . Nature (2020) .https: //doi.org/10.1038/s41586-020-2313-x