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It is only for medical professionals to read for reference.
You think it is not as good as catching a cold in the end, but in fact it has the ability to damage your brain.
"She once saw lions and monkeys
in
her own home .
She looked confused and showed aggressive aggressiveness towards others.
And I am convinced that her husband is a liar
.
"-This is the first case of developing mental illness after contracting the new coronavirus
.
The patient was a 50-year-old woman who was several decades older than the usual mental illness.
She had no history of mental illness before infection, but she developed mental symptoms of delirium after infection
.
In the early days of the new coronavirus epidemic, people focused their energy on treating lung and circulatory system damage, learned how to prevent epidemics, developed vaccines, and gradually developed a means to fight the new coronavirus
.
It has been suggested that the new coronavirus will eventually evolve into a common cold with mild symptoms after a long period of proliferation.
This is based on the view introduced by an article published in Science in February this year.
The study described the new coronavirus through modeling.
The severity and the nature of human coronaviruses (HCoVs) have concluded that if the new coronavirus reaches a stable endemic state and is first exposed to children, its virulence may not be stronger than the common cold
.
But over time, people have discovered that things are not that simple.
Perhaps the new coronavirus will not be as powerful as the common cold in the future, but now it has brought about a problem that cannot be ignored: the long-term symptoms of the new coronavirus
.
In layman's terms, long-term symptoms are also called sequelae.
The medical profession once wrote in "What are the sequelae of new coronary pneumonia?" These 5 long-term symptoms should be paid attention to.
According to the article, a large-sample population study conducted by FAIR Health found that nearly one-quarter of patients with new coronary disease are still suffering from long-term symptoms after being diagnosed for a month or more.
The nervous system of some patients is affected-the nervous system and related complications caused by virus damage to the brain are often very serious
.
In the FAIR Health study, anxiety and depression accounted for more than 2% and 1% of long-term symptoms.
In addition to the aforementioned delirium and anxiety, patients may also experience memory loss, stroke, cerebral hemorrhage, and cognitive dysfunction
.
Almost all of these thorny symptoms are not good.
Unfortunately, patients with these diseases may have to face these problems for a long time or even a lifetime
.
A study published in "JAMA" found that 80% of the hospitalized patients surveyed had neurological symptoms, which means that there are not a few patients whose brains are affected by the virus
.
Therefore, in order to prevent the situation of these patients from progressing to severe illness and leaving life-long regrets, it is particularly important to carry out intervention measures as soon as possible
.
Since the pandemic last year, researchers have been trying to figure out how the new coronavirus affects the brain.
Today, there is more and more evidence that the virus has multiple ways to attack the brain: it may directly attack some Brain cells reduce the blood flow to the brain tissue and may also cause the production of immune molecules that damage brain cells
.
Through these latest research results, it is expected to better point out the direction for the prevention and prognosis of brain damage caused by the new crown
.
Invasive brain researchers compared brain images before and after infection and found that several areas of the cerebral cortex had lost gray matter
.
Compared with normal controls, patients with new crowns have significantly reduced gray matter.
Some people have speculated that the virus may enter the brain and infect neurons in some way, but studies have found that it is difficult for the virus to pass through the blood-brain barrier and does not necessarily attack neurons.
It can infect astrocytes-a kind of cells that are abundant in the brain and have multiple functions.
They play a great role in supporting the normal operation of brain functions, such as providing nutrients to neurons to keep them working
.
The new coronavirus can also infect other brain cells, but it will preferentially infect astrocytes, and 66% of the infected brain cells are astrocytes
.
As astrocytes are infected, it can cause a series of neurological symptoms such as fatigue, depression and "brain fog"
.
The researchers also discovered that even if astrocytes are not infected by the virus, they may be affected indirectly, such as gene expression being affected, making them unable to work properly
.
Reducing blood flow in the brain The new coronavirus can also affect the brain by reducing blood flow to the brain, indirectly impairing the function of neurons, and ultimately killing them
.
Researchers have discovered that the new coronavirus can infect pericytes in the brain
.
Pericytes are cells that surround the endothelial cells in capillaries and veins throughout the body.
By blocking the function of pericytes, the virus causes the capillaries in the brain tissue to contract, causing a decrease in cerebral blood flow, or even a stroke.
The patient caused permanent damage
.
David Attwell, a neuroscientist at University College London, suggested that drugs used to treat high blood pressure may be useful for patients with this symptom.
There are currently two clinical trials investigating the effect of the antihypertensive drug losartan in the treatment of the disease
.
Increasing evidence that causes immune dysfunction indicates that some neurological symptoms and damage are caused by the body's own immune system overreacting
.
When the human immune system fights the new coronavirus infection, it may produce "autoantibodies" that attack its own tissues.
These autoantibodies can cross the blood-brain barrier and cause damage to the brain tissue, leading to neurological diseases ranging from memory disorders to mental illness
.
Researchers have found that intravenous injection of immunoglobulin can effectively inhibit the effects of harmful autoantibodies
.
The ways in which these viruses attack the brain are not mutually exclusive.
One or more of them may occur at the same time.
The causes of neurological symptoms in patients are also diverse.
"The key to treatment depends on the proportion of cases caused by each path
.
" German Neuroscience Harald Prüss, a neuroimmunologist at the Center for Degenerative Diseases, said
.
An opinion article published by "Nature" on July 8 proposed that the new crown virus may have three development directions in the future.
One is to further mutate more mutant strains, and the other is to evolve into a regional and seasonal disease similar to influenza.
The third is to degenerate into a common virus that only causes cold symptoms
.
For now, the third type is still unlikely to be realized
.
But even if the virus evolves into a flu-like disease in an area where the epidemic is relatively well controlled, the incidence and severity of its long-term symptoms are completely unmatched by ordinary flu
.
The United States released clinical data.
Among patients with long-term symptoms, 81% complained that they have cognitive dysfunction.
Although the severity is not enough to be hospitalized, it greatly affects the daily life of patients
.
Just imagine, if a patient recovers from the new coronavirus infection, but unfortunately leaves the complication of cognitive dysfunction, then he is likely to lose his job because of this, which will cause a heavy burden on the patient and his family.
.
Of course, it is not limited to neurological symptoms.
The long-term symptoms of the new coronavirus may also cause continuous damage to important organs such as the heart and lungs.
Studies have also shown that the new coronavirus will reduce the number of sperm in male patients and impair sperm function.
, Which in turn affects the fertility of men-the sequelae of the new coronavirus may affect the lives of patients in all aspects, which is by no means comparable to ordinary flu
.
Only by early intervention can patients be affected as little as possible by these sequelae
.
Reference source: [1]https://doi.
org/10.
1093/brain/awaa240 (2020)[2]DOI:10.
1126/science.
abe6522[3]DOI:10.
1001/jamanetworkopen.
2021.
12131[4]https://doi .
org/10.
1101/2021.
06.
11.
21258690[5]https://doi.
org/10.
1101/2021.
02.
15.
21251511[6]https://doi.
org/10.
1101/2021.
01.
17.
427024[7]https://doi.
org /10.
1101/2020.
10.
09.
20207464[8]https://doi.
org/10.
1038/s41586-021-03710-0[9]https://doi.
org/10.
1101/2021.
02.
09.
430349[10]DOI:10.
1016/j .
cell.
2020.
09.
049[11]https://doi.
org/10.
1038/s41586-021-03792-w
You think it is not as good as catching a cold in the end, but in fact it has the ability to damage your brain.
"She once saw lions and monkeys
in
her own home .
She looked confused and showed aggressive aggressiveness towards others.
And I am convinced that her husband is a liar
.
"-This is the first case of developing mental illness after contracting the new coronavirus
.
The patient was a 50-year-old woman who was several decades older than the usual mental illness.
She had no history of mental illness before infection, but she developed mental symptoms of delirium after infection
.
In the early days of the new coronavirus epidemic, people focused their energy on treating lung and circulatory system damage, learned how to prevent epidemics, developed vaccines, and gradually developed a means to fight the new coronavirus
.
It has been suggested that the new coronavirus will eventually evolve into a common cold with mild symptoms after a long period of proliferation.
This is based on the view introduced by an article published in Science in February this year.
The study described the new coronavirus through modeling.
The severity and the nature of human coronaviruses (HCoVs) have concluded that if the new coronavirus reaches a stable endemic state and is first exposed to children, its virulence may not be stronger than the common cold
.
But over time, people have discovered that things are not that simple.
Perhaps the new coronavirus will not be as powerful as the common cold in the future, but now it has brought about a problem that cannot be ignored: the long-term symptoms of the new coronavirus
.
In layman's terms, long-term symptoms are also called sequelae.
The medical profession once wrote in "What are the sequelae of new coronary pneumonia?" These 5 long-term symptoms should be paid attention to.
According to the article, a large-sample population study conducted by FAIR Health found that nearly one-quarter of patients with new coronary disease are still suffering from long-term symptoms after being diagnosed for a month or more.
The nervous system of some patients is affected-the nervous system and related complications caused by virus damage to the brain are often very serious
.
In the FAIR Health study, anxiety and depression accounted for more than 2% and 1% of long-term symptoms.
In addition to the aforementioned delirium and anxiety, patients may also experience memory loss, stroke, cerebral hemorrhage, and cognitive dysfunction
.
Almost all of these thorny symptoms are not good.
Unfortunately, patients with these diseases may have to face these problems for a long time or even a lifetime
.
A study published in "JAMA" found that 80% of the hospitalized patients surveyed had neurological symptoms, which means that there are not a few patients whose brains are affected by the virus
.
Therefore, in order to prevent the situation of these patients from progressing to severe illness and leaving life-long regrets, it is particularly important to carry out intervention measures as soon as possible
.
Since the pandemic last year, researchers have been trying to figure out how the new coronavirus affects the brain.
Today, there is more and more evidence that the virus has multiple ways to attack the brain: it may directly attack some Brain cells reduce the blood flow to the brain tissue and may also cause the production of immune molecules that damage brain cells
.
Through these latest research results, it is expected to better point out the direction for the prevention and prognosis of brain damage caused by the new crown
.
Invasive brain researchers compared brain images before and after infection and found that several areas of the cerebral cortex had lost gray matter
.
Compared with normal controls, patients with new crowns have significantly reduced gray matter.
Some people have speculated that the virus may enter the brain and infect neurons in some way, but studies have found that it is difficult for the virus to pass through the blood-brain barrier and does not necessarily attack neurons.
It can infect astrocytes-a kind of cells that are abundant in the brain and have multiple functions.
They play a great role in supporting the normal operation of brain functions, such as providing nutrients to neurons to keep them working
.
The new coronavirus can also infect other brain cells, but it will preferentially infect astrocytes, and 66% of the infected brain cells are astrocytes
.
As astrocytes are infected, it can cause a series of neurological symptoms such as fatigue, depression and "brain fog"
.
The researchers also discovered that even if astrocytes are not infected by the virus, they may be affected indirectly, such as gene expression being affected, making them unable to work properly
.
Reducing blood flow in the brain The new coronavirus can also affect the brain by reducing blood flow to the brain, indirectly impairing the function of neurons, and ultimately killing them
.
Researchers have discovered that the new coronavirus can infect pericytes in the brain
.
Pericytes are cells that surround the endothelial cells in capillaries and veins throughout the body.
By blocking the function of pericytes, the virus causes the capillaries in the brain tissue to contract, causing a decrease in cerebral blood flow, or even a stroke.
The patient caused permanent damage
.
David Attwell, a neuroscientist at University College London, suggested that drugs used to treat high blood pressure may be useful for patients with this symptom.
There are currently two clinical trials investigating the effect of the antihypertensive drug losartan in the treatment of the disease
.
Increasing evidence that causes immune dysfunction indicates that some neurological symptoms and damage are caused by the body's own immune system overreacting
.
When the human immune system fights the new coronavirus infection, it may produce "autoantibodies" that attack its own tissues.
These autoantibodies can cross the blood-brain barrier and cause damage to the brain tissue, leading to neurological diseases ranging from memory disorders to mental illness
.
Researchers have found that intravenous injection of immunoglobulin can effectively inhibit the effects of harmful autoantibodies
.
The ways in which these viruses attack the brain are not mutually exclusive.
One or more of them may occur at the same time.
The causes of neurological symptoms in patients are also diverse.
"The key to treatment depends on the proportion of cases caused by each path
.
" German Neuroscience Harald Prüss, a neuroimmunologist at the Center for Degenerative Diseases, said
.
An opinion article published by "Nature" on July 8 proposed that the new crown virus may have three development directions in the future.
One is to further mutate more mutant strains, and the other is to evolve into a regional and seasonal disease similar to influenza.
The third is to degenerate into a common virus that only causes cold symptoms
.
For now, the third type is still unlikely to be realized
.
But even if the virus evolves into a flu-like disease in an area where the epidemic is relatively well controlled, the incidence and severity of its long-term symptoms are completely unmatched by ordinary flu
.
The United States released clinical data.
Among patients with long-term symptoms, 81% complained that they have cognitive dysfunction.
Although the severity is not enough to be hospitalized, it greatly affects the daily life of patients
.
Just imagine, if a patient recovers from the new coronavirus infection, but unfortunately leaves the complication of cognitive dysfunction, then he is likely to lose his job because of this, which will cause a heavy burden on the patient and his family.
.
Of course, it is not limited to neurological symptoms.
The long-term symptoms of the new coronavirus may also cause continuous damage to important organs such as the heart and lungs.
Studies have also shown that the new coronavirus will reduce the number of sperm in male patients and impair sperm function.
, Which in turn affects the fertility of men-the sequelae of the new coronavirus may affect the lives of patients in all aspects, which is by no means comparable to ordinary flu
.
Only by early intervention can patients be affected as little as possible by these sequelae
.
Reference source: [1]https://doi.
org/10.
1093/brain/awaa240 (2020)[2]DOI:10.
1126/science.
abe6522[3]DOI:10.
1001/jamanetworkopen.
2021.
12131[4]https://doi .
org/10.
1101/2021.
06.
11.
21258690[5]https://doi.
org/10.
1101/2021.
02.
15.
21251511[6]https://doi.
org/10.
1101/2021.
01.
17.
427024[7]https://doi.
org /10.
1101/2020.
10.
09.
20207464[8]https://doi.
org/10.
1038/s41586-021-03710-0[9]https://doi.
org/10.
1101/2021.
02.
09.
430349[10]DOI:10.
1016/j .
cell.
2020.
09.
049[11]https://doi.
org/10.
1038/s41586-021-03792-w
