-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Recently, the journal Nature published a study online by Akico Iwasaki of Yale University School of Medicine and his team entitled "Sex differences inimmune responses that underlie COVID-19 disease outcomes".
the report explores the gender differences in COVID-19 and the possible immunological mechanisms behind them.
DOI: 10.1038/s41586-020-2700-3 Researchers tested viral load, SARS-CoV-2 specific antibody titration, plasma cell factors, and blood cell esotypes in patients with COVID-19.
results showed higher levels of several important inflammatory congenital immunodeficiration factors and cytokines in male patients, which may be associated with a higher number of non-classical monocytes.
the first sample of the virus load, anti-SARS-CoV-2 antibody titration, the researchers found that female patients have a stronger T-cell response.
of cd8-T cells increased significantly in female patients, while in male patients they were comparable to healthy populations.
by analyzing patients' clinical performance and transition, the researchers found that poor T-cell response in male patients was associated with disease development, while high innocular immunocytokine levels in female patients were associated with a worsening of COVID-19.
, there was a significant age-negative correlation in T-cell response in male patients.
differences in disease progression in patients these data show key differences in immune responses between men and women in the early stages of SARS-COV-2 infection and reveal possible immunological mechanisms.
Although this study has some limitations, it can provide ideas for further study of COVID-19 gender differences, and provide the basis for more efficient COVID-19 prevention, care, treatment and prognosios research.
overall, male patients may be more likely to need treatment for SARS-CoV-2's T-cell immune response, while female patients may be better suited to treatments that inhibit innate immunoactivation early in the disease.
resources: s1. Sex differences in immune responses that underlie COVID-19 disease outcomes.
