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Researchers at the Massachusetts General Hospital (MGH) recently studied aspects related to white blood cell production
Their research was published in "Nature Cardiovascular Research", entitled " Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease "
Abnormal hematopoietic function produces too many inflammatory white blood cells, which attack arteries and the heart, thereby promoting the occurrence of cardiovascular disease,” the researchers wrote
"Patients with heart disease have more white blood cells," said senior author Matthias Nahrendorf, MD, a researcher at the MGH Center for Systems Biology and a professor of radiology at Harvard Medical School
Researchers studied human bone marrow and mice and found that hypertension, atherosclerosis, and heart attack all cause changes in the number of blood vessels in the bone marrow
Nahrendorf explained: “Therefore, there will be more white blood cells in the body.
Research results show that cardiovascular disease affects the bone marrow vascular system, thereby affecting the activity of hematopoietic stem cells
"This work provides a new explanation for the important role of the vascular bone marrow niche and how inflammation occurs," said the National Heart, Lung, and Blood Institute under the National Institutes of Health.
