Nature Sub-Journal: The largest single-cell RNA sequencing project in history! The first discovery of glioblastoma stem cells is expected to inhibit cancer cells.

In this paper, the author: Lauren introduction: glioblastoma is the most malignant astrocytoma in astrocytoma, the growth rate is extremely fast, 70% - 80% of patients with disease course in 3-6 months, the course of disease more than 1 year is only 10%, after active treatment, it is very likely to relapse and rapid progress in half a year to a year.therefore, it is an important problem to control the recurrence of glioblastoma to reduce its mortality.a deeper understanding of how cancer begins, develops, and acquires resistance to treatment depends in part on a deeper exploration of cancer stem cell biology.glioblastoma is the most common adult primary brain cancer, and the research on stem cell biology of glioblastoma is limited.recently, a study found a cancer cell structure derived from a single cancer cell type, which can be used to slow down the growth of cancer cells.this study is the largest single cancer cell RNA sequencing project to date, including 55000 glioblastoma cells and 20000 normal brain cells.the researchers compared the genealogical hierarchy of the developing human brain with the transcriptome of cancer cells.the results showed that there were five major cancer cell types in each tumor, which were similar to those in normal human brain.single cell RNA sequencing highlights the transcriptome heterogeneity of glioblastoma and glioblastoma stem cells. For the first time, researchers have detected what they described as glioblastoma stem cells (GSCs), a cell type from which all other cancer cells develop.they showed that the cellular grade of the tumor originated from glioma stem progenitor cells.the results of this study, published in the journal Nature communications, are entitled "single cell RNA SEQ findings that glioblastoma receptors a normal neurodevelopmental hierarchy".the researchers wrote that they found "a conserved triple line cancer system centered on glial progenitor like cells.this progenitor group contains the circulating cells of most cancer cells, and, using RNA velocity, is usually the initiator of other cell types."RNA sequencing of developing brain single cells and identification of glial progenitor cells found that GSCs of progenitor cells divide more than mature cancer cells. Although they account for a relatively small proportion in the whole tumor, they constitute the vast majority of mitotic cells in tumors.these rapidly dividing cells are the earliest cancer cells that can be detected in the hierarchy, so they become promising therapeutic targets.after identifying the molecular vulnerability of progenitor cells GSCs, the researchers found that the survival and proliferation of progenitor cells GSCs decreased.in preclinical disease models, this reduces tumor growth and improves survival. Kevin petrica, neurosurgeon and brain cancer researcher at the Montreal Neuroscience Institute and hospital of McGill University "Our work has made great progress in addressing the complexity of the heterogeneity of glioblastoma and provides a new framework for reconsidering the nature of glioblastoma," said Dr. petrecca. as part of this work, our research also shows that, unlike decades of dogma, glioblastoma stem cells are the most rapidly dividing cancer cells in tumors, and we have identified new methods for targeting these cells. in this disease, it is not clear how these cancer cells interact with the cancer microenvironment, but this study can be a good starting point to understand how glioblastoma occurs and develops before treatment. "the fetal brain roadmap shows a three line structure of glioblastoma centered on progenitor cells. In summary, the team created a hierarchical map that can be used to identify specific therapeutic targets of cancer progenitor stem cells. research analysis shows that normal brain development coordinates the development of glioblastoma, suggesting the possible source of glioblastoma levels and helping to identify specific targets of cancer stem cells. reference: [1] [2] recommended reading: fighting the epidemic situation, translational medicine network content team series report: [JAMA] large retrospective cohort study in the United States: statins use can reduce the risk of cardiovascular disease and death in the elderly [quick news] single cell sequencing technology application salon was successfully held in Zhangjiang, Shanghai! [new progress] Australian scientists develop new blood testing methods to help treat invasive prostate cancer