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Nature sub-journal: Scientists reveal the cause of colon cancer recurrence after chemotherapy!

 Last Update: 2022-08-19
 Source: Internet
 Author: User

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Introduction: About 1 in 25 people will develop colon cancer in their lifetime, and nearly 2 million new cases are diagnosed each year worldwid.

Led by ICREA researcher and director of the IRB Barcelona Colorectal Cancer Laboratory, D.

is still no substitute

Chemotherapy is currently one of the most effective means of treating cancer, and together with surgery and radiotherapy, it is called the three major cancer treatment.

Organoids, patient sample analysis

The study was primarily conducted using organoids, which are tumor samples from patients (or mouse models of advanced cancer) that can be grown in the laboratory and reproduce the complexity of tumors in terms of their three-dimensional structure and variability in cell type.

The study also involved using a mouse model of colorectal cancer, in which researchers were able to observe and reproduce the behavior of these persistent cells, like organoid.

Mex3a gene

In addition, D.

Future laboratory work will focus on analyzing the underlying molecular mechanisms, specifically how the Mex3a protein maintains cancer stem cells in this dormant stat.

References:

This article is intended to introduce the progress of medical research and cannot be used as a reference for treatment plan.

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