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The cell membrane of the dividing cell is recessed along the center, dividing the cell into two almost identical daughter cells
How a cell takes on a unique shape, movement, division and organization is controlled by the mechanical force inside the cell
"In order to understand how cells generate power and shaping its form, actomyosin unlock the mode of action is crucial," an article entitled "Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis," the article The author wrote .
"We believe that OptoMYPT will help understand various embryology and cell biology phenomena involving the actomyosin cytoskeleton," said NIBB professor and senior author of the article, Dr.
This tool is designed to inactivate the non-muscle myosin II responsible for actomyosin contractility
The first author of the paper and graduate student Kei Yamamoto said: “We used a tool called iLID to control the positioning of proteins through light
The authors pointed out that irradiating blue light on mammalian cells and frog embryos is sufficient to dephosphorylate and inactivate myosin, thereby reducing cell contractility
The author points out: "We found that with OptoMYPT, the relaxation of the cortical tension at the poles accelerates the groove intrusion rate, which indicates that the cortical tension antagonizes the contraction of the sulcus to a large extent
When the researchers only weaken the tension of the cell cortex on one side of the dividing cell, an oscillating flow of cytoplasm occurs between the two daughter cells, causing them to deform
The productive application of OptoMYPT in understanding the mechanisms of cell division shows that the tool can be used to probe cell and tissue mechanics
