Nature Sub-journal: New drug successfully stops cancer metastasis!

May 2, 2020 /
Bio-Valley BIOON/- Researchers at the Francis Crick Institute have discovered a drug that is patient-tolerant and prevents cancer from recurring in mice One of the biggest challenges of cancer research is to prevent cancer recurrence in patients who have already been treated One reason for these relapses is that some cancer cells survive and grow into new tumor
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In a study published in the journal Nature Communications, researchers demonstrated an experimental drug, Quiinotat, that can prevent the regrowth of tumor
s and prevent the spread of human cancer cells that survive in culture after initial treatment in live mice the drug works by increasing the number of tumor a protein called histone H1.0 in cells The protein blocks the replication of cancer cells, which prevents the growth of tumor
when the team tested the drug on tumor in mice, it stopped the of the tumor Also, when cells taken from breast cancer , lung cancer, or pancreatic cancer patients were tested, cancer cells were trapped in a non-dividing state researchers hope that if proven effective in further trials and clinical trials
, the drug could be used in treated patients to prevent any remaining cancer cells from returning the disease Importantly, the effect of cuscinostath does not depend on how cancer cells survive treatment, and differences between patients and different types of cancer may bring widespread therapeutic benefits "The effect of this drug is to inactive cells that promote long-term growth of cancer and cause the disease to recur," said Critina Morale Torre, lead laboratory scientist at the Crick Cancer Epigenetics Laboratory, lead author of the study These early findings have even suggested that it may be more effective than commonly used drugs to suppress the growth of tumors Further research is needed to determine whether the drug can prevent the recurrence of cancer, or whether it can be used for long periods to control someone's disease "
important, this early study also showed that quesinosta may affect cancer cells and are harmless to healthy cells "Just like stem cells /, stem cells continue to produce offspring to keep our normal tissues healthy, " says Paola Scaffidi, co-author of the research team at crick's cancer epigenetics laboratory, research team leader and professor at the Cancer Institute at University College London." That's why finding a potential drug that stops tumors grow without harming normal cells is a challenge Excitingly, in the initial study, we found that using cuscinos would not harm healthy stem cells
/ stem cells "
next step for these researchers will be to understand why Quisinos has different effects on healthy and malignant cells, and whether histone H1.0 can tell us what makes cancer cells different from stem cells ." (Bio ValleyBioon.com) References: 's "I'm not sureabout for the cancer', Morale Torre, C., Wu, M.Y., Hobor, S et al.
Selective inhibition of cancer cell elf-renewal over a Quinotat-hitone H1.0 axi.
 Nat Commun 11, 1792 (2020) http://doi.org/10.1038/41467-020-15615-z