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Enzymes are proteins
"It's impossible to study each of these natural enzymes experimentally in the lab, there are so many of
Only the most promising enzymes need to be tested
Enzyme turnover numbers, or kcat values, describe how quickly and efficiently enzymes work and are critical
Given the amount of enzymes produced naturally, the researchers believe the new computational model could be very important
"We see many possible biotechnology applications
Learn more about enzyme production
More possible applications are more efficient production of products made from natural organisms than industrial processes
Eduard Kerkhoven said: "Understanding which enzymes can be harnessed can greatly help in the development and manufacture of new natural products
The computational model can also indicate changes in kcat values if the enzyme mutates, and identify unwanted amino acids
"We can reveal whether these enzymes have any 'part-time' activity and produce suboptimal metabolites
The researchers tested their model
Journal Reference:
Feiran Li, Le Yuan, Hongzhong Lu, Gang Li, Yu Chen, Martin K.
