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Chemotherapy has been an important means of cancer treatment since its invention, but the shortcomings of chemotherapy are also very obvious.
In addition to killing cancer cells, chemotherapy also kills normal cells, such as killing cells in hair follicles, leading to hair loss; Damages the digestive tract
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In addition to killing cancer cells, chemotherapy also kills normal cells, such as killing cells in hair follicles, leading to hair loss; Damages the digestive tract
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Digestion
Recently, Mikhail Shapiro 'steam atthe California Institute of Technologypublished a research paper entitled: Ultrasound-controllable engineered bacteria for cancer immunotherapy in the journal Nature Communications
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Recently, Mikhail Shapiro 'steam atthe California Institute of Technologypublished a research paper entitled: Ultrasound-controllable engineered bacteria for cancer immunotherapy in the journal Nature Communications
The research developed genetically engineered Escherichia coli to express tumor-inhibiting nanobodies and temperature-sensitive gene regulatory switches .
The research team used the Nissle 1917 E.
coli strain, which has been approved for human medical use
The research team used the Nissle 1917 E.
To turn these bacteria into useful tools for treating cancer, the research team genetically engineered them to contain two additional sets of new genes
By adding temperature-dependent genes and nanobody genes, the research team created bacterial strains that produced tumor-suppressing nanobodies only when heated to a trigger temperature of 42-43°C
Since human solid tumors are usually located deep in the body, how can the bacteria at these tumor sites be heated in a targeted manner? The research team used focused ultrasound (FUS) technology, using ultrasound as an energy source to transmit multiple beams of ultrasound from outside the body into the body, focusing on the tumor during the launching process, and converting sound waves and thermal energy to form within 0.
5-1 second.
Since human solid tumors are usually located deep in the body, how can the bacteria at these tumor sites be heated in a targeted manner? The research team used focused ultrasound (FUS) technology, using ultrasound as an energy source to transmit multiple beams of ultrasound from outside the body into the body, focusing on the tumor during the launch process, and converting sound waves and thermal energy to form within 0.
Using focused ultrasound technology, the above-mentioned genetically engineered bacteria can be activated in tumors
The experimental results showed that tumor mice treated with the engineered bacteria plus ultrasound had slower tumor growth than mice with tumors treated with ultrasound alone, mice treated with the engineered bacteria alone, and mice with tumors that were not treated.
many
The experimental results showed that tumor mice treated with the engineered bacteria plus ultrasound had slower tumor growth than mice with tumors treated with ultrasound alone, mice treated with the engineered bacteria alone, and mice with tumors that were not treated.
According to the research team, this study shows that genetically engineered bacteria + ultrasound therapy is a promising tumor treatment method
.
The team will further optimize genetically engineered bacteria and ultrasound to achieve more precise heating stimulation
.
.
The team will further optimize genetically engineered bacteria and ultrasound to achieve more precise heating stimulation
.
precise
Paper link:
Paper link:https:// Leave a message here