Nature Sub-Journal: Exercise brings muscle stem cells back to old age in mice!

February 25, 2020 / / -- According to a new study by researchers at Stanford University School of Medicine, short trips on a turntable every night can enhance muscle repair in older mice.
only older mice could get the benefit, the researchers found, which was due to the regeneration of muscle stem cells in animals.
"The impact on older animals is remarkable," said Thomas Rando, M.D., a professor of neurology and neuroscience at Stanford University and director of Stanford University's Glenn Center for Aging Biology.
" we found that regular exercise can restore tissue repair to youth.
the appearance and behavior of their muscle stem cells began to look like those of much younger animals.
also found a molecular pathway involved in reversing the cell clock.
believe that drugs that control this pathway may be effective alternatives to exercise.
Rando is the senior author of the study, which was published recently in the journal Nature Metabolism.
source: Unlike embryonic or induced erythrogenic stem cells, the potential of tissue-specific stem cells is limited.
embryos or induce erypotent stem cells to produce any tissue in the body.
stem cells along the muscle fibers in a state known as resting until they are asked to repair the damage.
and others have shown that tissue regeneration decreases with age, due to a decline in adult stem cell function," said Rando, a research scientist.
researchers are looking for a way to restore youth.
"lifestyle adjustments" are not found to be a reliable source of youth, but it is well known that certain lifestyle adjustments are beneficial.
Is known to reduce the risk of a variety of age-related diseases, including cardiovascular disease, cancer, and possibly even Alzheimer's disease," said Rando, a research spokesman.
people want to know how exercise brings these health benefits.
, the researchers wanted to know whether and how autonomous exercise affected the function of muscle stem cells in mice.
they exposed mice about 20 months old (equivalent to 60-70 years old in humans) and mice aged 3 to 4 months (equivalent to people between the ages of 20 and 30) to a sports wheel and let them run at will.
mice ran an average of 10 kilometers a night, and older mice ran about 5 kilometers.
two other groups of young and old mice were given non-rotating wheels as a control group.
animals exercise at the intensity they feel comfortable with, just as people do for their own health," said Rando, a spokesman for the animals.
this situation is less stressed than resistance training or intense endurance exercise, which in itself may affect the function of muscle stem cells.
" subsequent analysis showed that the muscle stem cells of moving animals remained stationary and that the animals did not produce a large amount of new muscle fibers after exercise.
three weeks of nighttime aerobic exercise, the researchers compared the animals' ability to repair muscle damage.
found that, as expected, sedentary older mice were significantly less able to repair muscle damage than sedentary young mice.
, older animals that exercise regularly are significantly better at repairing muscle damage than older animals that don't exercise.
the benefits of this exercise were not observed in young animals.
same result occurred when muscle stem cells from older mice that had exercised were transplanted into young mice.
stem cells in the exercise group contributed more to the repair process than stem cells in the non-motor group.
The study of the benefits of young blood also showed that injecting the blood of older mice that had exercised into older mice that had not exercised had a similar effect, suggesting that exercise stimulation produced certain factors and entered the blood circulation, thereby enhancing the function of aging stem cells.
photo source: "It's really interesting," the study says, showing that blood in young mice appears to improve tissue stem cells in older mice to some extent.
further studies have shown that the motion-induced regeneration observed by the researchers could be simulated by adding an expression of a signal molecule called cyclin D1, which is involved in waking up stationary muscle stem cells to cope with damage.
findings suggest that it may one day be possible to artificially activate this pathway to keep aging muscle stem cells at their best at a young age.
we can develop a drug that mimics this effect, we may not have to do months of exercise to experience the benefits," said Rando, a researcher at the university.
" () Reference: Exercise restores youthful properties to muscle stem cells of old miceExercise rejuvenates quiescent skeletal muscle stem cells in old mice through life of Cyclin D1, Nature Metabolism (2020). DOI: 10.1038/s42255-020-0190-0.