Nature Sub-Journal: Bone transplants generated by primitive stem cells promote stubborn fracture healing!

, June 27, 2020 /PRNewswire/-- While most fracture
s can be repaired with solid plasters and extensive care, more complex fractures require treatmentsuch as bone transplantsResearchers at Texas Agricultural University have developed excellent bone grafts using primitivestem cellsThey found that these cells can help the bones regenerate in the fertile scaffolding needed at the repair siteresearchers say these grafts can be used to promote rapid and precise bone healing, allowing patients to maximize the benefits of surgical interventions" orthopaedic implants can cause problems such as inflammation and painIn addition, they may be loose and require resustom surgery, which is usually much more complex than the previous implanted surgeryTherefore, by accelerating the bone healing process, our materials can potentially reduce the number of these repair operationsThe researchers published their findings in the June issue of the journal Communications CommunicationsPicture Source: DrCarl Gregoryin the United States, about 600,000 people experience bone healing delays or incompleteness each yearIn some of these cases, doctors perform surgery to transplant bone tissue to the repair siteThese bone transplants usually come from two sources: an entomiher bone transplant from another part of the patient's body, and a deeply processed human carcasshowever, both types of bone grafts have their own drawbacksFor example, an entomotic bone transplant requires additional surgery to extract bone tissue, increase the patient's recovery time, and sometimes cause chronic painOn the other hand, the grafts extracted from the body bones rule out the need for two operations, but these grafts often lack many biomolecules that promote bone repair"some of the physical properties of bone transplants from the body bones, even a bit biological, but in terms of function they are very poor." DrCarl Gregory, an associate professor at Texas Agricultural University's Center for Health Sciences and co-author of the study, saidWhat we want to do is design a bone transplant that we can experimentally accelerate recovery and, arguably, make it more biologically active"
previous studies have shown thatstem cell, especially a cell called interstitialstem cell, can be used to produce bioactive bone transplantsIn particular, these cells are converted into bone cells to produce the stents or extracellular matrixes needed for bone growth and survivalhowever, thesestem cellsare usually extracted from the bone marrow of the adult bone, so they are olderTheir age affects the ability of cells to divide and produce more precious extracellular matrixes to solve this problem, researchers turned to the cell ancestor of interstitial stem cells-- pluripotent stem cells Unlike adult interstitial hyperplial cells with relatively short lifespans, these primitive cells can continue to multiply, creating an unlimited supply of interstitial stem cell required to manufacture bone-transplanted extracellular matrixes They added that multi-energy cells could be made by genetic recombination of donated adult cells when researchers experimented with the ability to induce pluripotent stem cells to produce new interstitial stem cell , they were able to produce an extracellular matrix that was much more biologically active than the interstitial cells obtained from the bone "Our material sits not only with the biomolecules needed to make most of the thick bone tissue, but also rich in growth factors that drive vascular formation," said Gregory, "
to test the effect of stent material as bone transplantation, they carefully extracted and purified the rich extracellular matrix and then implanted it in the bone defect site After several weeks of bone repair, they found that their pluripotent stem cells derived matrix esquire five to six times more effective than the best FDA
-approved transplant stimulator Picture Source: "Using the transplant gold standard bone repair experiment, like those using a powerful bone growth stimulant called bone formation protein-2, takes about eight weeks, but we can fully heal in four weeks," said Gregory, nature communications Therefore, under these conditions, our material is far more effective than bone-shaped protein-2, which suggests that it is a huge improvement in current bone repair techniques the researchers also say that from a clinical point of view, the grafts can be combined with a large number of engineering implants, such as 3d-printed implants or metal screws, so that these parts can bind better to the surrounding bones They also point out that bone grafts will also be easier to produce and are therefore beneficial from a production point of view "Our material is very promising because the of pluripotent stem cells can ideally produce many batches of extracellular matrix from a donor, which will greatly simplify the large-scale manufacture of these bone grafts," said Gregory, " (BioValleyBioon.com) References: Primitive stem cells point to new bone grafts for deorentacity-to-heals fracture Eoin P McNeill et al, Characterization of a plurient stem cell-derived dyded matrix with osteorare
sonrer DOI: 10.1038/s41467-020-16646-2