Nature: structure of dopamine transporter is determined
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Last Update: 2013-11-07
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Source: Internet
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Author: User
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Dopamine transporter (DAT) is a membrane protein that removes dopamine, a neurotransmitter, from the synaptic space and inputs it into the cytosol of surrounding cells, thus terminating the neurotransmitter signal Eric gouaux and colleagues reported the X-ray structure of the Drosophila dat combined with the tricyclic antidepressant, "demetrine." This is the first crystal structure of a eukaryotic neurotransmitter sodium co transporter The overall structure of DAT in Drosophila is similar to LeuT, but the author also found several differences, which may play an important role in eukaryotic protein transport mechanism and regulation of phosphorylation.
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