Nature: Scientists have analyzed 97,691 genomes to reveal the genetic causes of the cloning process!

October 19, 2020 // -- Scientists from Massachusetts General Hospital and other institutions have revealed the genetic causes of clone-induced hematopoiesis by analyzing the entire genome of 97,691 individuals in a study published in the international journal Nature entitled "Inherited causes of clonal haematopoisis in 97,691 whole genomes".
Age is a major risk factor for chronic diseases in most humans, but researchers do not yet know the molecular mechanisms behind the disease risks mediated by aging; in regenerative hematopoietic stem cell populations, the development of age-related somatic cell mutations leads to the expansion of cloning, which has recently been shown to be associated with human blood cancer and coronary heart disease Directly related, this phenomenon is called "uncertain potential cloning hematopoietic effect" (CHIP, clonal haematopois of indeterminate potential);
Photo Source: In the Frontiers study, researchers analyzed the genome-wide sequences of 97,691 individual organisms from different ancestors in the Precision Medicine Cross-Histology (TOPMed) project from different ancestors from the National Heart, Lung and Blood Institute, and eventually identified 4,229 individuals with CHIP status. In the
article, the researchers identified a very specific association between blood cells, lipid properties, and inflammatory characteristics of different CHIP-driven genes, and finally found a group of genomic lineage genetic mutations that could help them identify three genetic points associated with CHIP status, including TAT2 bits, which are specific to individuals of African descent.
researchers say in-body evaluation of TET2 line points may help effectively identify mutations that interfere with the function of TET2 far-end enhancers, which can lead to increased levels of self-renewal of hematopoietic stem cells.
In general, in this study, the researchers observed how genetic mutations in the lineage shape the function of hematopoietic stem cells, thus inducing the formation of CHIP, which may be achieved through a specific mechanism of cloning hematopoietic action and a sharing mechanism leading to mutations in somatic cells between different tissues.
() Original source: Alexander G. Bick, Joshua S. Weinstock, Satish K. Nandakumar, et al. Inherited causes of clonal haematopoiesis in 97,691 whole genomes, Nature (2020) doi:10.1038/s41586-020-2819-2