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Nature reveals for the first time the mechanism of herpes virus invading the nervous system

 Last Update: 2022-01-01
 Source: Internet
 Author: User

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More than half of American adults are carriers of HSV1 (herpes simplex virus type 1), which is dormant in the peripheral nervous system and can never be eradicated

As a close relative of HSV1, HSV2 is more commonly transmitted through sexual contact and can be passed from mother to newborn as a newborn herpes during delivery

In a new study, researchers from Northwestern University's Fernberg School of Medicine revealed the cunning strategy of HSV1 to infect the nervous system, which opened a long-needed vaccine development path for HSV1 and HSV2

This new research has discovered a route to vaccine development

Hitchhiking

Like many viruses, the herpes virus jumps on train tracks called microtubules in cells and uses protein engines called dynein and kinesin to move along the tracks

Herpes virus travels "international"

Think of the host cell as a railway platform

When a more typical virus, such as the influenza virus, infects mucosal epithelial cells (cells that line your nose and mouth), it grabs these two engines and moves back and forth on the microtubule bundles until it finally or more Or less accidentally reach the nucleus

But traveling along the nerves is equivalent to a cross-country trip

But the dynein engine cannot take it farther than the centrosome

Note: The original text has been deleted

Reference materials:

Caitlin E.

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