Nature: reveal how B cells produce new antibodies

November 16, 2019 / Biovalley BIOON / - -- in a new study, researchers from Boston Children's Hospital in the United States learned more about the process of V (d) J recombination and how to use chromatin looping to collect fragments to be spliced The relevant research results were recently published in the journal Nature, and the title of the paper is "basic roles of chromium loop expansion in antilogy class switching" In this paper, the researchers outlined their research and their understanding of how immune cells match genetic code fragments to produce new antibodies The picture is from cc0 public domain As these researchers point out, a lot of research has been devoted to understanding how the human immune system works One finding is that when new threats are discovered, immune cells can mix and match certain pieces of the genetic code to produce new antibodies But until now, this mixing and matching process has been a mystery In this new study, the researchers set out to learn more about its working mechanism The researchers knew from the beginning that the recombination process of V (d) J would make the immune system produce new antibodies They also point out that DNA strands are packaged with proteins into chromatin containing multiple rings When the body detects a new threat, these rings in the chromatin pull DNA fragments closer in the distance This study shows how B cells use ring formation in chromatin to produce new antibodies They found that rag enzymes were coupled to the mechanism involved in the first step of V (d) J recombination, forcing D and j to connect Next, when the chromatin ring is formed, the DNA crosses the rag complex At the same time, other factors prevent chromatin ring extrusion, which pauses DNA movement and allows rags to enter This allows gene substrate fragments to be presented to the rag complex for V (d) J recombination They also found that a protein called cohesin is involved in this chromatin ring extrusion / rag process They also pointed out that although their work focused on the V (d) J recombination process, they believed that their findings would have an impact on other processes involved in gene regulation (BIOON Com) reference: 1 Xuefei Zhang et al Fundamental roles of chromium loop extension in antibody class switching Nature, 2019, DOI: 10.1038/s41586-019-1723-0 2 Study reeals more about how immune cells create new types of antibodies https://mediaexpress.com/news/2019-10-reeves-immune-cells-antibodies.html