Nature: Qinchuan et al. reveal the pathogenicity of SARS-CoV-2 in hACE2 genetically modified mice

2020 May 13 News /BioValleyBIOON / - Severe Acute Respiratory Syndrome CoV-2 (SARS-CoV-2) led to the 2019 crown virus disease (COVID-19) case, has become a public health emergency of international concern, leading to hundreds of thousands and millions of people infected diedSource: Naturetaking into account the angiotensin-converting enzyme 2 (angiotensin-transferase2, ACE2) is a SARS-CoV5 cells into the recipient, Qin Chuan team from the Institute of Experimental Animals Chinese Academy of Medical Sciences and Beijing Key laboratory of emerging infectious diseases from animal models, team collaboration Center for comparative Medicine Beijing Union Medical College and the national Institute for prevention and control of viral and other units to study the use and carrying of human ACE2 transgenic mice infected with SARS-CoV-2's the pathogenicity of the virusRelated research recently published in Nature, entitled "ThepathogenicityofSARS-CoV-2inhACE2transgenicmice"Co-corresponding author Professor Qin Chuan Institute of Medical Laboratory Animal Chinese Academy of Medical Sciences, China CDC viral disease Control and Prevention researcher Wu Guizhenresearchers observed weight loss and viral replication in the lungs of mice infected hACE2 SARS-CoV-2'sThe researchers found that the typical histopathology interstitial pneumonia, endoplasmic seen clearly alveolar macrophages and lymphocytes, alveolar macrophage accumulationresearchers virus antigen was observed in bronchial epithelial cells, alveolar macrophages and epithelial cellsBut this phenomenon is not found in SARS-CoV-2 infected with wild-type miceNotably, the researchers demonstrated 2 SARS-CoV-hACE2 pathogenic in miceThe researchers said SARS-CoV-2 infection in a mouse model of great significance for the assessment of antiviral therapy and vaccines as well as understanding the pathogenesis of COVID-19a (Biovalley Bioon.com) References:.Bao, L., Deng, W., Huang, B.etalThepathogenicityofSARS-CoV-2inhACE2transgenicmiceNature ( 2020) .https: //doi.org/10.1038/s41586-020-2312-y