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April 25, 2021--In post-live animals, specific tasks are often placed in specialized organs, and these organs have been established in the early stages of development.
Nature 's organs may become more and more immune throughout the course of life, and this view may change the views of scientists on the rules of immunization and the function of the body's immune system
Image source: https:// the article, the researchers focused on related research on T cell immunity.
Historically, research on the body’s immune system has always emphasized the use of the regenerative properties of bone marrow, lymphatic organs and blood
The specific pathogen-free mice living with the pet shop mice revealed the expansion of the body's tissue immunity in response to the human-like microbial experience
Image source: Wijeyesinghe, S.
Nature
Researchers have also accidentally discovered that T cells residing in tissues may serve as the origin of memory T cells in the blood.
In summary, the results of this article show that “living” (rather than renewal or recycling) may become an important feature of non-lymphocyte surveillance, and organs, as adaptive reservoirs, may hold the cellular immune system during the entire life stage.
, “Living” (rather than renewal or recycling) may become an important feature of non-lymphocyte surveillance, while organs serve as adaptive reservoirs, or can accommodate the continuous expansion of the cellular immune system throughout life; although hematopoietic function can Help restore certain functions of the immune system, but non-lymphoid organs can maintain continuous tissue-autonomous cellular immune accumulation, which will lead to the gradual dispersion of the body’s immune balance .
Original source:
Wijeyesinghe, S.
Wijeyesinghe, S.
, Beura, LK, Pierson, MJ et al.
Expansible residence decentralizes immune homeostasis .
Nature 592, 457–462 (2021).
doi: 10.
1038/s41586-021-03351-3 Expansible residence decentralizes immune homeostasis Nature