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This article is original by Translational Medicine Network.
Please indicate the source for reprinting.
Author: Tiffany Guide: Gene therapy refers to a method of modifying genetic material (DNA or RNA) to achieve the purpose of treatment
.
Compared with traditional drugs, gene therapy has the advantages of good targeting and more thorough treatment, and is considered to be a new type of treatment with broad prospects in the future
.
At present, some gene therapies have been approved, and the treatment targets include genetic diseases, cancer, etc.
, while gene therapy for many other diseases is undergoing extensive clinical trials
.
A group of scientists have recently discovered the role of gene therapy in the treatment of cancer and dementia.
.
.
Recently, researchers at the University of Sheffield have discovered a new approach to gene therapy, revealing a way to help our genome maintain An important regulatory mechanism for health
.
This approach can protect us from cancer, dementia and other life-threatening and life-shortening serious diseases
.
Cancer and neurodegenerative diseases are two types of diseases that currently affect human life and are fatal.
They constitute two aspects of the same problem, and this common problem is the problem of genome damage: of the two types of diseases, one is caused by Genome damage leads to uncontrolled cell proliferation, and the other is caused by cell death caused by excessive damage to the genome
.
Scientists recently discovered a new approach that can not only help humans prevent these two diseases to a large extent, but also provide enlightenment and new effective methods for how to treat cancer patients and dementia patients
.
They published the results of this research in an article titled "USP11 controls R-loops by regulating senataxin proteostasis" in the journal Nature Communications: Scientists found that when cells in our body read DNA to build proteins, they often There will be mistakes, and these mistakes will cause our genome to be destroyed, and eventually bring us diseases such as cancer and dementia
.
However, by studying how cells repair DNA damage so that our health can be maintained, scientists have discovered the benefits of three proteins working together and working together
.
The three proteins called USP11, KEAP1 and SETX can cooperate and operate together to provide continuous support for our health because they receive instructions from the "commander" and then through their high coordination.
Guide their functions in space and time, so as to ultimately provide continuous support for the health of DNA
.
By understanding how cells avoid making mistakes and thereby avoiding certain high-risk diseases in humans, scientists can modify the behavior of these proteins to ultimately achieve the goal of promoting people's health
.
This discovery can help scientists develop diagnostic testing methods and drugs that target one or more proteins for early detection and early treatment of certain types of cancer and neurological diseases; development of the ability to regulate one or more protein levels The new drug is expected to provide new treatments for cancer and dementia patients
.
Professor Sherif El-Khamisy, co-founder and deputy director of the Institute for Healthy Life, University of Sheffield, and Professor Sherif El-Khamisy from the School of Biological Sciences and Institute of Neuroscience, University of Sheffield, said: "These findings are not only important for our research, they are important for future clinical trials.
The significance of treatment is also particularly significant, because we are now at a stage where we can develop drugs to control this microscopic change
.
The drugs we develop will help kill cells, which is what we do when treating elderly cancer patients
.
Another use of these drugs is to reduce the extent of genome damage, thereby helping to alleviate diseases such as dementia
.
"Reference material: https://medicalxpress.
com/news/2021-09-gene-therapy-pathway-cancer-dementia.
html Note: This article is intended to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
If you need health guidance , Please go to a regular hospital for treatment
.
Popular·Article Scientific Research [NEJM] It's time for us to change the salt! A landmark study proved that simply changing the salt can prevent millions of deaths every year.
Scientific research [Nature Sub-Journal] Unprecedented clarity and speed: For the first time, the new microscope technology recorded more than 1 million neurons in the entire mouse brain Cortical activity gene detection [Nature Sub-Journal] The 1.
5 million largest genome-wide association study has identified nearly 600 gene loci related to anti-social behavior, alcoholism, and opioid addiction.
New crown virus [NEJM New Crown] in the world The largest new coronavirus vaccine safety research results released liquid biopsy [Science Sub-Journal] Biomarkers that can be determined based on blood samples-predict patient response to immunotherapy The safest medicine for the treatment of new crown infections!" The clinical trial results are out! Organoids [Nature Sub-Journal] The use of 3D brain organoids induced by stem cells can accurately replicate human brain cancer early screening [Nature Sub-Journal] A new non-invasive early screening method for lung cancer based on blood cfDNA, with a super high detection rate! Organoids [Science Sub-Journal] Subversion! It is the first time that a complete living tumor is 3D printed, and cancer exploration has entered the "real" 3D era.
Gene editing [Nature Sub-Journal] is a heavyweight! Academician Ye Yuru’s team used genome editing technology to treat Alzheimer’s disease and achieved a major breakthrough in early cancer screening [The Lancet] Subverted traditional detection methods and achieved a new breakthrough in early prostate cancer screening.
Scientific research [Discovery] Recounted Nobel Prize winners in 1944 According to the experimental data of Vitamin C, it was found that the 2 times the recommended dose recommended by the WHO should be used.
Activities The 3rd Shanghai International Cancer Conference The 5th Modern Clinical Molecular Diagnosis Symposium
Please indicate the source for reprinting.
Author: Tiffany Guide: Gene therapy refers to a method of modifying genetic material (DNA or RNA) to achieve the purpose of treatment
.
Compared with traditional drugs, gene therapy has the advantages of good targeting and more thorough treatment, and is considered to be a new type of treatment with broad prospects in the future
.
At present, some gene therapies have been approved, and the treatment targets include genetic diseases, cancer, etc.
, while gene therapy for many other diseases is undergoing extensive clinical trials
.
A group of scientists have recently discovered the role of gene therapy in the treatment of cancer and dementia.
.
.
Recently, researchers at the University of Sheffield have discovered a new approach to gene therapy, revealing a way to help our genome maintain An important regulatory mechanism for health
.
This approach can protect us from cancer, dementia and other life-threatening and life-shortening serious diseases
.
Cancer and neurodegenerative diseases are two types of diseases that currently affect human life and are fatal.
They constitute two aspects of the same problem, and this common problem is the problem of genome damage: of the two types of diseases, one is caused by Genome damage leads to uncontrolled cell proliferation, and the other is caused by cell death caused by excessive damage to the genome
.
Scientists recently discovered a new approach that can not only help humans prevent these two diseases to a large extent, but also provide enlightenment and new effective methods for how to treat cancer patients and dementia patients
.
They published the results of this research in an article titled "USP11 controls R-loops by regulating senataxin proteostasis" in the journal Nature Communications: Scientists found that when cells in our body read DNA to build proteins, they often There will be mistakes, and these mistakes will cause our genome to be destroyed, and eventually bring us diseases such as cancer and dementia
.
However, by studying how cells repair DNA damage so that our health can be maintained, scientists have discovered the benefits of three proteins working together and working together
.
The three proteins called USP11, KEAP1 and SETX can cooperate and operate together to provide continuous support for our health because they receive instructions from the "commander" and then through their high coordination.
Guide their functions in space and time, so as to ultimately provide continuous support for the health of DNA
.
By understanding how cells avoid making mistakes and thereby avoiding certain high-risk diseases in humans, scientists can modify the behavior of these proteins to ultimately achieve the goal of promoting people's health
.
This discovery can help scientists develop diagnostic testing methods and drugs that target one or more proteins for early detection and early treatment of certain types of cancer and neurological diseases; development of the ability to regulate one or more protein levels The new drug is expected to provide new treatments for cancer and dementia patients
.
Professor Sherif El-Khamisy, co-founder and deputy director of the Institute for Healthy Life, University of Sheffield, and Professor Sherif El-Khamisy from the School of Biological Sciences and Institute of Neuroscience, University of Sheffield, said: "These findings are not only important for our research, they are important for future clinical trials.
The significance of treatment is also particularly significant, because we are now at a stage where we can develop drugs to control this microscopic change
.
The drugs we develop will help kill cells, which is what we do when treating elderly cancer patients
.
Another use of these drugs is to reduce the extent of genome damage, thereby helping to alleviate diseases such as dementia
.
"Reference material: https://medicalxpress.
com/news/2021-09-gene-therapy-pathway-cancer-dementia.
html Note: This article is intended to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
If you need health guidance , Please go to a regular hospital for treatment
.
Popular·Article Scientific Research [NEJM] It's time for us to change the salt! A landmark study proved that simply changing the salt can prevent millions of deaths every year.
Scientific research [Nature Sub-Journal] Unprecedented clarity and speed: For the first time, the new microscope technology recorded more than 1 million neurons in the entire mouse brain Cortical activity gene detection [Nature Sub-Journal] The 1.
5 million largest genome-wide association study has identified nearly 600 gene loci related to anti-social behavior, alcoholism, and opioid addiction.
New crown virus [NEJM New Crown] in the world The largest new coronavirus vaccine safety research results released liquid biopsy [Science Sub-Journal] Biomarkers that can be determined based on blood samples-predict patient response to immunotherapy The safest medicine for the treatment of new crown infections!" The clinical trial results are out! Organoids [Nature Sub-Journal] The use of 3D brain organoids induced by stem cells can accurately replicate human brain cancer early screening [Nature Sub-Journal] A new non-invasive early screening method for lung cancer based on blood cfDNA, with a super high detection rate! Organoids [Science Sub-Journal] Subversion! It is the first time that a complete living tumor is 3D printed, and cancer exploration has entered the "real" 3D era.
Gene editing [Nature Sub-Journal] is a heavyweight! Academician Ye Yuru’s team used genome editing technology to treat Alzheimer’s disease and achieved a major breakthrough in early cancer screening [The Lancet] Subverted traditional detection methods and achieved a new breakthrough in early prostate cancer screening.
Scientific research [Discovery] Recounted Nobel Prize winners in 1944 According to the experimental data of Vitamin C, it was found that the 2 times the recommended dose recommended by the WHO should be used.
Activities The 3rd Shanghai International Cancer Conference The 5th Modern Clinical Molecular Diagnosis Symposium
