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Nature Neuroscience: fMOST helps build a global database of single-cell projectionomics

 Last Update: 2022-09-21
 Source: Internet
 Author: User

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The prefrontal cortex (PFC) is the center of the mammalian brain's execution of advanced cognitive functions such as learning, memory, attention, and emotion

Projectionomics features of single-celled neurons

Academician Luo Qingming's team used the fluorescence microscopic optical slice tomography system (fMOST) to acquire images of 161 sparsely labeled mouse brain tissues, capturing the axon morphology of 6357 individual projecting neurons in the PFC region, with a total length of 783.

Figure 1: Axon morphological typing of 6357 individual projected neurons in the PFC region

Characteristics of the distribution of axon collateral of single-cell projection neurons

According to the projection of IT neurons into different sub-networks, its primary axonal branches are also divided into 4 subclusters

Figure 2: Structural characteristics of individual projected neurons in the PFC region

Tranchomics and single-cell projectionomics

Nine subtypes of cortical projection neurons were found using a single-cell transcriptomics database: Lypd1 and Penk can label layer 2/3 IT neurons, Rorb, Deptor and Nnat can label layer 5-6 IT neurons, Npnt and Lypd1 can label PT neurons, and Nnat and Tpbg can label CT neurons

Figure 3: Transcriptomics features versus projection omics features

summary

This paper reveals the spatial projection structure characteristics

【References】

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