Nature: Nature reveals how the body's 'steriliser' became an accomplice to cancer metastasis, promising to stop the spread of cancer

Neutrophils areimmunecells that provide the body with the first line of defense againstinfectionHowever, this line of defense is sometimes less "strong" because neutrophils also have the ability to promote cell cell metastasis, sometimes "inverting" cancer cellsJune 11, professor Song Erwei, a member of the Chinese Academy of Sciences and dean of Sun Yat-sen Memorial Hospital at Sun Yat-sen University, published a study published online in nature, revealing the special mechanismby by which neutrophils help cancer cells to metastasize and spreadhttps://doi.org/10.1038/s41586-020-2394-62004, researchers first discovered that neutrophils were able to form a mesh structure (NET) outside their cellsThis is a DNA network that is encased in enzymes that are toxic to microorganisms and can capture and kill invading microorganismsHowever, there is growing evidence that NETs are also involved in tumor sourcing in the distant processA process that helps cancer cells spreadTo uncover the mechanism by which neutrophils help spread tumor metastasis, the researchers first evaluated NET in primary and metastatic tumors in 544breast cancerpatients, and found that large amounts of neutrophil immersion appeared in the liver before the tumor metastasis, the researchers also observed that a receptor on the surface of cancer cells called "CCDC25" can bind to NET DNA with high specificity and affinity, making NET a chemometric factor for tumor cells, "attracting" cancer cells in the breast, colon, etcto the liver to form new tumors "If, by imaging, a large group of neutrophils in the patient's liver is detected when breast cancer has not metastasized, it means that he has a high risk of liver metastasis," said Song In further experiments, CCDC25 showed the ability to remove cancer cells from in vitro cultured human breast cancer cells Removing CCDC25 from the surface of mouse cancer cells compared to mice with Lipopolysaccharide molecule (LPS) induced inflammation treatment significantly reduced liver metastasis and lung metastasis at the end of the report, the researchers revealed how tumor cells benefit from this interaction with the network Using CCDC25 as a "bait" in biochemical techniques, they screened CCDC25-interactive proteins from cancer cells to identify a protein-integrator-linked kinase (ILK), which regulates processes such as cell migration and proliferation When ILK is removed or its downstream signal ingon seis pedagogis is disabled, the growth and in vitro movement of cancer cells are severely impaired, and in mice, transfer to the liver is reduced Emma Nolan and Ilaria Malanchi of the Francis Crick Institute in the UK, commented in a paper published in Nature that the study represents a key development in curbing the spread of cancer and could help researchers develop a specific strategy to stop THE NET from promoting cancer metastasis In addition, the data provided in the paper also point to possible ways to predict liver metastasis by monitoring NET DNA in the blood Of course, further research is needed to assess the feasibility of targeting CCDC25 for cancer treatment