Nature: Microbes regulate intercom neurons through the intestinal-brain circuit.

July 17, 2020 /PRNewswire/ -- The connection between the gut and the brain monitors the gut tissue and its microbes and diet, regulating the physiological functions of the intestines, such as nutrient absorption and rhythm, and eating behaviors linked to the brainAs a result, there may be circuits that detect intestinal microorganisms and transmit information to the central nervous system region, which in turn regulates the physiological mechanisms of the intestinesResearchers from Rockefeller University and others recently wrote in Nature that they described the effects of the microbiome on intestinal-related neurons by combining transcription groups, circular tracking methods and functional operations, in a study entitled "Microbiota modulate the neurons via gut a gut-brain circuit"Photo: Researchers found that the gut microbiome regulates intestinal intersympathetic neurons: The absence of the microbiome leads to an increase in the expression of neuron transcription factor cFos, and bacteria that produce short-chain fatty acids are fixed in sterile mice and later intersects inhibit the expression of the intestinal sympathetic nerve sectionThe researchers showed that a group of vagus nerve cells projected by the far end of the intestine, projected by the far end of the intestine, were identified through chemical genetic manipulation, translational spectrometry and tracing, which were positioned to act as an inductor in the regulation of microbially mediated intestinal dissothing nerve cellsThe tracer of retrograde multisy-synaptic neurons from the intestinal wall identified the brain stem sensory nucleus activated during microbial consumption, as well as the pre-glutamate energy neurons that regulate gastrointestinal transportOverall, these results reveal a new mechanism for controlling intestinal exogenous intercourse nerve activation through intestinal-brain circuit-dependent microorganisms() References: Muller, P.A., Schneeberger, M., Matheis, Fet alMicrobiota Modulate islam synas a gu-brainNature (2020)https://doi.org/10.1038/s41586-020-2474-7.