Nature is a major development! Simulated fasting diet and hormone therapy inducebreast cancer subside!

July 17, 2020 // About 75% of breast cancers express estrogen and/or progesterone receptorsEndocrine therapy is usually effective for these hormone receptor-positive tumors, but primary and acquired drug resistance limits their long-term efficacyRecently, researchers from the University of Genoa, the University of Southern California and other units found that in mouse models of hormone-receptor-positive breast cancer, periodic fasting or simulated fasting increased the activity of endocrine therapy tamoxifen and fluorovis, primarily by reducing the circulation of IGF1, insulin and leptin, and by increasing the transmission of EGR1 and PTEN adypt AKT-mTOR signals, and the results of the study were published as "The PHOTO SOURCE: Researchers found that increasing the periodic cycle of a fasting-like diet can promote long-term tumor decline and reverse acquired drug resistance when used in combination with Pabosini, a kinase 4/6 inhibitor that relies on cycle proteinsThe researchers found that fasting and a diet similar to fasting could prevent endometrial hyperploff caused by tamoxifenIn addition, the researchers found that when patients with hormone-positive breast cancer received estrogen therapy, the metabolic changes caused by simulated fasting cycles were similar to those observed in mice, including lower levels of insulin, leptin and IGF1, and the last two levels remained low for long periods of timeIn mice, these long-lasting effects were associated with long-term anti-cancer activity, the researchers saidOverall, these results support further clinical studies to explore whether simulating fasting in hormone-receptor-positive breast cancer as an auxiliary treatment for estrogen therapy can help patients produce a better anti-cancer response() References: Caffa, I., Spagnolo, V., Vernieri, Cet alFasting mimic-de-diet-the-sin-the-singy-therapy-dorsa-ding-cancerNature (2020)https://doi.org/10.1038/s41586-020-2502-7.