Nature: Intestinal microbiome may affect the prognosis of people with amyotrophic lateral sclerosis

, June 7, 2020 /
PRNewswire/ -- In a recent study published in the international journalNature, scientists from Harvard University and others identified a new type of intestinal-brain connectivity in the neurodegenerative disease myatrophic lateral sclerosis (ALS) and studied mice thatantibiotics or brain transplantsPicture Source: CC0 Public Domain
The findings may help explain why some individuals experience mutations that induce ALS, and microbiome researchers may also be able to develop a possible therapeutic approachResearcher Kevin Eggan said: 'In this study, we focused on the most common mutant genes in the body of ALS patients, and found that the same mouse model (the samegeneticcharacteristics) may show significantly different health outcomes under different experimental facility conditions;researchers studied alS gene mutations by developing mouse models in the lab, where the immune response of mice, including inflammation of the nervous system and other parts of the body, induces a shorter life span; 'At this point, we may be exposed to the broader scientific community because different study mice study the samegeneticmouse models and observe different findings, and then the researchers collect and sequence microbiome samples from different laboratories, and find that very similar gut microflora is associated with the severity of disease in mice hundreds of miles apart,' said Burberry, a researcher at theby investigating the association between genetic characteristics and environmental factors in THE body of ALS patients, the researchers identified an important intestinal-brain connection, and they say that the gut microbiome may affect the severity of the disease, i.ewhether individuals carryinggenetic mutations develop ALS, or associated with prefrontal temporal dementia, or have no symptoms, so the gut microbiome may be a target for the development of new therapies 'In this study, we delve into the molecular mechanisms behind ALS, including the most common ALS genetic mutations that induce nerve inflammation, and the intestinal-brain axis is involved in a range of neurological disorders, including Parkinson's disease and Alzheimer's disease, and the importance of this intestinal-brain axis is underscored,' said Eggan, the 's final researcher (BioValleyBioon.com) original origins: Burberry, A., Wells, M.F., Limone, F et al.
C9orf72 suppresses systemic and neural yn yr by gut bacteria.
Nature 582, 89-94 (2020) doi: 10.1038/s41586-020-2288-7