Nature: Immune "yin and yang" who regulates? HDAC3 protein is key.

Introduction: Immunity is the body's self-protection behavior, resistance to foreign enemy infection and invasion, the exclusion of alien molecules, including the aging of their own dead cells.
appropriate immune response can remove pathogens, which is beneficial to the body.
but excessive immune response can harm the body itself.
, then, what is the key to regulating the body's immunity? Inflammation is a very common and important basic pathological process, in the inflammatory process, on the one hand, damage factors directly or indirectly cause damage to tissues and cells, on the other hand, through inflammatory congestion and oozing reaction, to dilute, kill and surround the damage factors.
also repair and heal damaged tissue through the regeneration of both substantive and intersogen cells.
it can be said that inflammation is a unified process of injury and anti-injury.
is a unified process of injury and anti-injury, and the key to regulating the immune response to inflammation has been one of the focus of the researchers' research.
, researchers at the Perelman School of Medicine at the University of Pennsylvania found that a protein called histone deacetylase 3 (HDAC3) is a coordinating factor in the immune system's fight against infection.
the use of specially cultured cell and small animal models, HDAC3 was found to be directly involved in the production of drugs that help kill harmful pathogens and restore balance in the body, i.e. the balance of the body.
the study, published August 5 in the journal Nature, is entitled "Dichotomous engagement of HDAC3 activity activity event responses".
the study suggests that some of the methods being tested to combat cancer and harmful inflammation, such as sepsis, target molecules with HDAC3 that can actually have unintended and fatal consequences.
, senior author of the study and director of the Institute of Diabetes, Obesity and Metabolism (IDOM), said the study's authors were "very important." "Our work shows that HDAC3 is the key to an innitive immune response because its yin and yang function can trigger inflammation as well as reduce it," said Mitchell A. Lazar, a professor at the U.S. Government.
, HDAC3 requires targeted treatment when tested for drugs and used to fight potentially fatal inflammation.
" inflammation is a highly complex defense mechanism used by the innate immune system, which means it is an innate thing that is not obtained like the rest of the immune system.
inflammation is known for its swollen appearance, it also includes changes in blood flow and vascular permeability, as well as the migration of white blood cells.
if well organized, the inflammatory response can quickly and accurately locate and eliminate the risk, and then enter the anti-inflammatory process to help remove damaged tissue and allow the body to begin healing and repair.
, however, the body's inflammatory response can sometimes damage itself.
, cancer, heart disease, diabetes and even coVID-19 can occur when the rise and fall of inflammatory factors is not controlled.
inflammation can lead to infectious shock, which can lead to multiple organ failure in the body due to uncontrollable "cytokine storms", a phenomenon that has also been widely reported in patients with COVID-19 infections.
therefore, the discovery of HDAC3 as an inflammatory coordination factor has broad implications.
, researchers used a variety of advanced genomic techniques to isolate and locate HDAC3.
protein plays a large role as an enzyme, a catalyst that causes different reactions in the body.
team found a mechanism by which it transitions between different enzymatic states, which allows it to activate and inhibit inflammatory reactions.
to test the actual effects of the enzyme, the researchers looked at three different reactions to toxins in mouse models.
, they looked at the lack of HDAC3 models in macrophages.
macrophages are cells used by the immune system to destroy harmful substances in the body.
, high levels of protection against infectious toxins can be observed.
in different models, when HDAC3 exists and allows it to perform its typical enzyme function, there is a moderate protective effect and mortality, consistent with the expectations of the toxin when it exists.
but in the third model, when the enzyme activity of HDAC3 is completely blocked by its own mutant form, the lethality increases dramatically and sepsis begins to appear.
noteworthy that these apply only to HDAC3 in macrophages.
while the lack of HDAC3 molecules in those immune system cells works best, efforts to remove them completely from the body can be disastrous because it helps form the cells the body needs to survive.
, the researchers hope their work will provide information for ongoing drug-level research.
hdAC inhibitors as a way to fight cancer and inflammation have been of great concern.
toxins used in this study produce an inflammatory cytokine storm that is very similar to severe new coronavirus infections," Said Lazar said.
our study suggests that if human cytokine storms are like mice, targeting HDAC3 proteins rather than their enzyme activity may reduce the virus's lethality.
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