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    Home > Active Ingredient News > Study of Nervous System > Nature: Immune cells actually secrete neurotransmitters to limit tumor immunity

    Nature: Immune cells actually secrete neurotransmitters to limit tumor immunity

    • Last Update: 2021-11-13
    • Source: Internet
    • Author: User
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    Lymphocytes are regulated by the interaction of various receptors with soluble and cell-bound proteins
    .


    However, small metabolites from immune cells are also abundant in certain tissues, many of which may have signal potential that remains to be understood


    Immune water-soluble metabolites can be used as environmental clues to mediate the interaction between immune cells.


    Recently, researchers discovered that the metabolite and neurotransmitter GABA is a candidate signal molecule synthesized and secreted by activated B cells and plasma cells
    .

    Metabolite and neurotransmitter GABA is a candidate signal molecule synthesized and secreted by activated B cells and plasma cells Metabolite and neurotransmitter GABA is a candidate signal molecule synthesized and secreted by activated B cells and plasma cells

    GABA is a major inhibitory neurotransmitter that regulates communication between neurons
    .


    Outside the brain, GABA has been detected in the intestines, spleen, liver, and pancreas


    However, the cell source of GABA other than pancreatic β cells and neurons is still unknown
    .


    Although GABA precursors glutamine and glutamate are abundant in B cells and bone marrow cells, B cells are characterized by abundant GABA content, whether in resting (contralateral) or activated (ipsilateral) popliteal lymph nodes In


    In addition, in non-targeted MS analysis of lymph nodes in mice or lymphocytes in human peripheral blood, GABA and other glutamate metabolism components are relatively more abundant in B cells
    .


    Analysis of the two converts glutamate to GABA in key enzymes that compared with T cells encoding glutamic acid decarboxylase 67 (GAD67) transcripts in mouse and human B cells are elevated , which This indicates that glutamate metabolism is characteristic of B-lineage cells in both species


    GABA and other glutamate metabolism components are relatively more abundant in B cells GABA and other glutamate metabolism components are relatively more abundant in B cells The transcript encoding glutamate decarboxylase 67 (GAD67) is relatively abundant in mouse and human B cells are elevated encoding glutamic acid decarboxylase 67 (GAD67) transcripts in mouse and human B cells are elevated

    B cells limit the anti-tumor response through GABA
    .

    B cells limit the anti-tumor response through GABA
    .


    B cells limit the anti-tumor response through GABA


    B cell-derived GABA promotes monocytes to differentiate into anti-inflammatory macrophages, secretes interleukin-10, and inhibits the killing function of CD8+ T cells.


     

    Original source:

    Original source:

    Baihao Zhang et al.


    Baihao Zhang et al.


     

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