Nature: Glutamine prevents muscle injury and aging

Nov 1, 2020 /--- -- A team led by Professor Massimiliano Mazzone (VIB-KU Leuven Center for Cancer Biology) has teamed up with Dr. Emanuele Berardi and Dr. Min Shang to reveal new metabolic dialogues between inflammatory cells and muscle stem cells.
researchers have shown that strengthening this metabolic crosstalk with GLUD1 inhibitors promotes the release of glutamine and improves muscle regeneration and body function in experimental models of muscle degeneration such as trauma, local isoemia and aging.
in addition to its transformational potential, this work has provided important advances in a number of research areas, including muscle biology, immunobolism and stem cell biology.
glutamine's skeletal muscle helps our bodies move, but it is also a large reserve of amino acids stored in protein form, which affects the body's energy and protein metabolism.
amino acid glutamine is considered essential for muscle metabolism because of its richness.
, however, its exact role after trauma or during chronic muscle delincation disorders is largely ignored.
masimiliano Mazzone's team observed that normal levels of glutamine in muscles decreased due to dead muscle tissue during damage or aging.
the metabolic dialogue between inflammatory cells that arrive after injury and lying muscle stem cells.
this cell crosstalk re-establishes the original level of glutamine in the muscles and promotes muscle fiber regeneration in the process.
regenerative muscle researchers using the latest techniques in vitro and the body showed that muscle damage, local isoemia and aging-related muscle wasting were characteristic of reduced glutamine.
one of the reasons for this is the loss of glutamine due to damage to the muscle itself.
Berardi explained: "Using genetic tools and the pharmacology of GLUD1, the enzyme that inhibits glutamine metabolism, we can prevent the decline of glutamine after injury.
this causes inflammatory cells called macrophages to overproduce glutamine and then reach muscle damage.
glutamine can be used by muscle stem cells to rapidly regenerate damaged muscle tissue.
found the same thing in acute and chronic degenerative diseases, such as aging, to restore muscle function faster.
" Study on Preventing Degeneration reveals glutamine as a sensor molecule that controls regeneration procedures at a level in muscle tissue, and suggests that GLUD1 is a therapeutic target that can provide opportunities for muscle regeneration after acute injury or chronic degenerative diseases, such as aging.
Mazzone highlighted the potential of its findings: "This offers hope for the treatment of degenerative muscle diseases, including trauma, local isoemia and aging.
With the increasing average age of the global population, the latter poses a major challenge to healthcare in particular, and in cooperation with VIB Discovery Discovery and the Center for Drug Design and Discovery, we are currently developing and testing more selective GLAD1 inhibitors to treat chronic muscular dystrophy, including muscular dystrophy.
" (Bioon.com) Source: Glut protectamines againstst muscle and aging Original source: Min Shang et al. Macrophage-derived glutamine boosts satellite cells and muscle regeneration, Nature (2020). DOI: 10.1038/s41586-020-2857-9