Nature: Details of The Status of Coronary Virus Vaccine Research: Illustrated Guide

May 26, 2020 /
BiovalleyBIOON/- Research teams at companies and universities around the world are developing more than 90 vaccines against SARS-CoV-2Researchers are experimenting with different technologies, some of which have never been used before for licensed vaccinesAt least six organizations have begun injecting volunteers with formula in safety trials; others have begun testing on animalsNature's graphic guide explains the design of each vaccineSARS-CoV-2 vaccine: Multiple methodsall vaccines are designed to expose the body to an antigen that does not cause disease, but triggeran an immune responseIn this case, if a person is infected with the virus again, the immune response can stop or kill the virusAt least eight types of coronavirus vaccines are being tried, and they depend on different viruses or parts of the viruspicture: Nik Spencervirus vaccine
at least seven research groups are developing a vaccine that uses the virus itself in the form of weakened or inactivated virusesMany existing vaccines are made this way, such as measles and polio vaccines, but they require extensive safety testingBeijing Kexing Biotech Co., Ltdhas begun testing an inactivated SARS-CoV-2 on humansimage source: Naturevirusvectorvaccine
about 25 organizations say they are working on the virusvectorvaccineViruses such as measles or adenoviruses are genetically engineered to produce coronavirus proteins in the bodyThese viruses are weakened, so they do not cause diseaseThere are two types: one that can be replicated within cells and the other that cannot be replicated because key genes are destroyedimage source: At least 20 research groupsnucleic acid vaccineare working to use genetic instructions (in the form of DNA or RNA) to produce a coronavirus protein that triggers an immune responseThe nucleic acid in this vaccine is inserted into human cells and then a copy of the viral protein is produced -- most vaccines encode the protrusion protein of the viruspicture: Natureprotein vaccine
Many researchers hope to inject coronavirus protein directly into the body Protein fragments or protein shells that mimic the coronavirus shell can also be used image source: More than 70 percent of the groups in the Industry Experiments leading vaccine research are from industrial or private companies clinical trials start with small-scale safety studies in animals and humans, followed by larger trials to determine whether the vaccine has an immune response Researchers are accelerating these steps in the hope of developing a vaccine within 18 months Picture Source: T Thanh Le et al Nature Rev Drug Disc
This chart shows the types of developers from different parts of the world who are developing coronavirus vaccines (BioValleyBioon.com) References: 1- The race for coronavirus vaccines: a
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