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From everyday actions like walking and talking, to athletic or academic excellence, the brain continuously captures and processes information seamlessly to produce these incredible behaviors
In a new report in the journal Nature, a team of researchers from the lab of Paola Arlotta, the Golub Family Professor of Stem Cell and Regenerative Biology and the Stanley Center for Psychiatry at the Broad Institute of MIT and Harvard, is about to answer this question.
Stogsdill continued: "When you're trying to affect the brain, you're not going to have to treat microglia as a blanket cell type
This research provides unique insights into how different types of cells work in harmony
In the paper, the scientists describe how neurons train microglia to work with them when they first meet early in the brain
"These different types of cortical neurons take in different numbers of microglia," Stogsdill said.
The cerebral cortex is organized into different layers, each with different neuron types
The team then built a molecular map outlining the communication between neurons and microglia
"We know that microglia can influence the function of neural circuits, and now we know that neurons can recruit specific types of microglia to their surroundings," Arlotta said
Pyramidal neuron subtype diversity governs microglia states in the neocortex
