Nature: Damaged adult neurons retreat to embryonic state for repair?
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Last Update: 2020-05-30
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Source: Internet
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Author: User
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Transplanted spinal neuroprogenites (NPCs) have a powerful regenerative ability to have cortical axons after spinal cord injury and help restore forelimb function, but until now, the molecular mechanism of this regeneration has been unknownrecently, researchers analyzed the team, particularly motor neurons in the mouse cortical spinal cord beam (CST), in search of spinal cord injury and 'regenerative transcription group' after NPC transplantationnotably, individual damage and damage combined with NPC transplantation caused almost identical early transcriptome reactions in host CST neuronsHowever, in mice with individual injuries, the regenerative transcription group was lowered after two weeks, and in mice transplanted by NPC, the transcription group was continuousthe regeneration transcription group represents the recovery of the embryo transcription state of CST neuronsThe Huntingtin gene (Htt) is the center of the regenerative transcription group, and the removal of Htt significantly reduces regeneration, suggesting that Htt plays a key role in the neuroplasticity after injury
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