Nature breakthrough: No.

For the first time, scientists have developed three types of organ system in the laboratory, an important step in the study of human development(Photo: Nature)The breakthrough was published in the journal Nature on September 25th, when a team of researchers from the United States and Japan successfully developed three interconnected organs, including the liver, pancreas and bile ducts, using induced pluripotent stem cells for the first time in the worldprevious development of human-like organs, tiny three-dimensional tissue cultures derived from stem cells that perform functions of multiple cell types found in full-size organs, has provided important support for scientific research, but this new development led by DrTakanori Takebe of Cincinnati Children's Hospital in the United States has enabled scientists to study how human tissue works togetherIn addition, this major breakthrough may begin to reduce the need for animal model-based drug research and accelerate the development of medical researchdr, DrTakanori Takebe (Photo: Cincinnati Children's Hospital)DrTakebe, 32, joined Cincinnati Children's Hospital in 2016 and also worked at tokyo Medical and Dental University in JapanHe had planned to become a liver transplant surgeon after graduating from medical school in 2011, but when he learned of the huge gap between donor organ supply and demand, he decided to do something to address the bottleneckin previous studies, Dr Takebe has developed a method that produces large amounts of liver buds, an early form of liver-like organsHe also developed liver organs that reflect the state of disease, such as fatty hepatitisIn the new study, Dr Takebe's team aims to grow multiple organs simultaneously using stem cellsThey devised a method to produce the tissue (pre-organ formation stage tissues) that corresponded to organ formation before it was formedSpecifically, the researchers started with human skin cells, converting them into primitive stem cells, and then guided and stimulated them to form two very early cells called globulars ("spheroids" of cells), roughly known as the pre-intestinal and middle intestines image source: Cincinnati Children's Hospital, Tokyo Medical and Dental University These cell "globulars" have formed in the early stages of embryonic development (specifically later in the first trimester of pregnancy) during human development Over time, these globular syllables merge and become organs, which eventually become the digestive tract cultivating these "globulars" in the laboratory is a complex process that requires the right "raw materials" to be used at the right time After a lot of work to get the two "globulars" of the front and middle intestines, Dr Takebe and others next placed them next in a special laboratory petri dish Two "globulars" are suspended in a gel commonly used to support organ growth and then placed on a thin film covered with a set of carefully mixed growth media images show the critical moment stakes in the intestinal organ's beginningto: the transition from two "globulars" to fusion proto-gut (a structure that shows the early formation of the liver, pancreas and the bile ducts) (Photo: Nature; DOI: HTTPs://doi.org/10.1038/s41586-019-1598-0 ) They found that cells from each "globular" began to transform after they met at the boundary, transforming themselves and each other into more specialized cells Then, very quickly, the fusion, ever-changing spheres branched, forming a new group of cells belonging to a particular organ Over a period of 70 days, these cells continue to evolve into more granular and unique cell types Eventually, the resulting mini liver-biliary-pancreatic organoid begins to process bile acids as if they were digesting and filtering food "It was completely unexpected because we thought that something needed to be added or otherfactors were needed to drive the process," said Hiroyuki Koike, lead author of the paper from Cincinnati Children's Hospital and Tokyo Medical and Dental University However, the failure to control this biological process led to our success Dr Aaron Zorn, director of the Center for Stem Cell and Organ Medicine at Cincinnati Children's Hospital , believes that Dr Takebe's team's integrated organ system is a real breakthrough that will not only provide unprecedented opportunities for studying normal human development (a connected organ system provides more information than three separately grown organs), but will also have a significant impact on disease diagnosis and treatment (for example, the current path to liver regenerative medicine lacks bile duct connectivity, which is expected to address the problem) small areas: Stem Cell Journal: Nature Highlights: A major breakthrough in induced pluripotent stem cells (iPSC) has been announced by research teams from the United States and Japan: for the first time in the world, iPSC has successfully produced three interconnected organs simultaneously, including the liver, pancreas and bile ducts Not only will this new development allow scientists to study how human tissueworks work together, but it may also begin to reduce the need for animal-based drug research and accelerate the development of medical research related papers: Nature (2019) references: 1's World's first organ o's systemo pens for medical research and diagnosis (source: Cincinnati Children's Hospital Medical Center) 2 ?