NATURE: Bohai/Zhong Yi/Hu Wei Group Joint Discovery: Brain-Spleen Axis Directly Regulates Vaccine-mediated Antibody Immune Response

It has been speculated that brain activity may directly control the adaptive immune response of lymphatic organs, but so far there is little evidence of thisrecently, researchers in China found that in mice, the deneural control of the spleen specifically impairs the formation of plasma cells during the T-cell-dependent immune response, but not t-cells' non-dependence immune responsethe production of spleen nerve activity to enhance the production of plasma cells requires the reactive of b cells to acetylcholine-mediated alpha9 niacin receptors, while T cells that express choline acetyltransferase may serve as a relay between the norepinephrine energy nerve and acetylcholine reaction B cellsresearchers also found that neurons that express corticosteroid-releasing hormones (CRH) in the central nucleus of the amygdala (CeA) and ventripartite nucleus (PVN) are connected to the spleen nerve;in a newly developed behavioral therapy that puts mice on elevated platforms, leading to the activation of CeA and PVN CRH neurons and increased plasma cell formationIn immune mice, elevated platform intake induced an increase in antigen-specific IgG antibodies, which relied on the expression of B-cell expression in CRH neurons in CeA and PVN, complete spleen nerves, and alpha9 acetylcholine receptorsthis study reveals the brain's control of adaptive immunity by determining a specific brain-spleen nerve connection, autonomously enhancing the body fluid response, and proving immune stimulation through physical behavior, and suggests the possibility of enhancing immune capacity through behavioral intervention