Nature: Anti-SARS-CoV-2 antibodies found to neutralise and protect the body.

July 17, 2020 /PRNewswire/ -- The COVID-19 pandemic is a major threat to global health, especially in areas where medical responses are limitedIn addition, we currently lack in-depth understanding of the mechanisms of body fluid immunity(S)(mAbs)S(SRBD)ACE2(hACE2),Nature,"Potently neutralizing and protective human antibodies against SARS-CoV-2"。 Photo Source: Researchers say competing binding, structure and functional studies allow for monoclonal antibody clustering to identify different epitopes on SRBD and different conformational states of the S-protein tripolymerThe researchers found that these neutral izedugosaual COV2-2196 and COV2-2130 were effective in identifying non-overlapping sites, combined with S proteins, and co-ordinated and true SARS-CoV-2 virusesThe researchers demonstrated in two mouse SARS-CoV-2 infection models that passive input COV2-2196 or COV2-2130 or combined with these two monoclonal antibodies protected mice from weight loss, reduced viral burden and lung inflammationIn addition, the researchers demonstrated that passive input of two of the most effective ACE2 blocking monoclonal antibodies (COV2-2196 or COV2-2381) as a single treatment can protect rhesus monkeys from SARS-CoV-2 infectionOverall, these results determine the protective epithet of SRBD and provide a structure-based framework for the rational design of vaccines and the selection of powerful immunotherapy() References: Zost, S.J., Gilchuk, P., Case, J.Bet alPotently neutralizing and the human antibodiesst SARS-CoV-2Nature (2020)https://doi.org/10.1038/s41586-020-2548-6.