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Nature Aging: the source of youth for the aging of bone marrow stem cells

 Last Update: 2021-10-01
 Source: Internet
 Author: User

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For some time, researchers have regarded epigenetics as a cause of the aging process
.
Epigenetics studies changes in genetic information and chromosomes.

These changes will not change the sequence of genes themselves, but will affect their activities

"We want to know why as we age, these stem cells produce less and less substances for bone development and maintenance, leading to more and more fat accumulation in the bone marrow
.
In order to do this, we compare "The epigenome of stem cells in young and old mice is analyzed," explains Andro machi Pouikli, the first author of the study

Epigenome regeneration

The researchers then investigated whether the epigenome of stem cells can be rejuvenated

To clarify whether this change in the epigenome may also be the cause of the increased risk of fracture or osteoporosis in the elderly, the researchers studied human mesenchymal stem cells from patients after hip surgery

A new treatment for osteoporosis?

"Sodium acetate can also be used as a food additive.
However, we do not recommend using it in this form to treat osteoporosis, because the effects we have observed are very specific to certain cells
.
" However, there are already stem cells for bone treatment.

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Journal Reference :

Andromachi Pouikli, Swati Parekh, Monika Maleszewska, Chrysa Nikopoulou, Maarouf Baghdadi, Ignacio Tripodi, Kat Folz-Donahue, Yvonne Hinze, Andrea Mesaros, David Hoey, Patrick Giavalisco, Robin Dowell, Linda Partridge, degradation to Peteratin remodeling .

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