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Senescent cells-cells that have stopped dividing-continue to accumulate in tissues throughout the body
This work was published in the journal Nature Aging, and the title of the paper is "Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology
Dr.
They developed a method of aging characteristic genes to identify rare senescent cells among a large number of different human brain cells after death
By analyzing tens of thousands of cells in the brains of people who died of AD, the research team found that about 2% of the cells were senescent cells
Next, Orr's team tried to determine whether aging neurons have tangles-abnormal accumulation of tau protein, which can be collected in neurons in AD
The researchers found that not only do aging neurons have tangles, but they overlap to the point where they are indistinguishable
The author points out that the cyclin-dependent kinase inhibitor 2D (CDKN2D/p19) is predicted to be the most important contributor to the main aging characteristic genes
The research team concluded that CDKN2D/p19 expressing neurons with NFTs represent a unique cell population with an senescence-like phenotype in human Alzheimer's disease
Orr said: "Now that we have identified these cells in the brain, we have opened the door to many possibilities, including treatment options for patients with Alzheimer's disease
Orr is launching a US$3 million Phase II clinical trial funded by the Alzheimer’s Drug Discovery Foundation (ADDF) to test the elimination of people with mild cognitive impairment or early Alzheimer’s The effect of senescent cells in the elderly
