Nature accidentally found out! SARS-CoV-2 antibodies are present in non-infected people!

July 17, 2020 /PRNewswire/ -- Previouspathogen-induced memory T cells can alter susceptibility and clinical severity to subsequent infectionsLittle is known about the presence of pre-existing memory T cells in humans with the potential to recognize SARS-CoV-2To uncover this secret, researchers from the Duke-NUS School of Medicine and the A-STAR Institute, led by Antonio Bertoletti, studied for the first time the Structure Area of T cells in patients with COVID-19 recovery (n-36) on THE structure of SARS-CoV-2 (nuclear-shell protein, NP) Reactions to non-structural areas (ORF1 NSP-7 and NSP13), published in Nature, entitled "SARS-CoV-2-specific Tmmunity i in case of COVID-19 and SARS, and uninfected controls"Photo Source: The researchers found that CD4 and CD8 T cells were able to identify multiple regions of the NP protein in all of the study participantsThe researchers also found that patients recovering from SARS (n-23) still had persistent memory T cells for THE SARS-NP response 17 years after the SARS outbreak in 2003, showing strong cross-reaction to SARS-CoV-2 NPSurprisingly, researchers also often detected SARS-CoV-2-specific T cells in individuals withnosic SARS, COVID-19, or patients exposed to SARS/COVID-19The SARS-CoV-2 T cells of the uninfected donor exhibit different patterns of immune advantage, usually targeting the ORF-1-encoded protein NSP7 and the NP structural proteinThe epitope characteristics of NSP7-specific T cells indicate that these T cells can identify low-hoe protein fragments associated with the "common cold" human coronavirus, but are more conservative in animal beta coronavirusesTherefore, the researchers believe that beta coronavirus infection induces T cells to produce multispecific and long-lasting immunity to the structural protein NPUnderstanding how NP and ORF-1-specific T cells in the general population affect susceptibility and pathogenesis of SARS-CoV-2 infection is critical to the management of the current COVID-19 pandemic, the researchers said() References: Le Bert, N., Tan, A.T., Kunasegaran, Ket alSARS-CoV-2-specific Tmmunity i in case of COVID-19 and SARS, and uninfected controlsNature (2020)https://doi.org/10.1038/s41586-020-2550-z.