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Researchers from the University of Texas at the University of San Antonio have identified 61 additional stroke-related gene loci and 6 genes that are potential targets for drug therapy to prevent or treat stroke
Stroke is the second leading cause of death worldwide, accounting for about 12% of all deaths, and is the leading cause
The co-author of the Nature article, Sudha Seshadri, MD, is a professor of neurology at the UT-Health San Antonio and Teresa Lozano Long School of Medicine and a founding director of
"The populations studied in this paper are of considerable global representation, including Africa, South Asia, East Asia, Europe and Latin America
Stroke is a major risk factor for dementia, and there is a great overlap
Study co-author Dr Claudia Satizabal said: "There is a common biology between stroke and dementia, and the approach used in this project to study stroke genetics will make us even stronger in studying dementia
Co-author Dr.
Current known drug targets in Alzheimer's disease and related dementia have so far not led to effective treatment
Over the next 10 years, driven by research such as the GIGASTROKE findings, dementia clinical care will "progress to taking blood samples from patients, looking at patients' genes, to understand what's happening in the brain, and to conducting targeted treatments
Stroke genetics informs drug discovery and risk prediction across ancestries