Natto can not be used in the treatment of hemolytic thrombus

Natto is a popular food on Japanese table In many parts of southern China, the ancient way of eating beans is similar to that of natural fermentation Modern science has found that natto is rich in nattokinase, isoflavone, lecithin and other nutrients Natto has become the darling of healthy diet Even in Japan, there has been an event of "advocating natto lose weight and cause natto sell out" After Japanese cardio cerebrovascular experts found that nattokinase in natto has the effect of dissolving thrombus, nattokinase, the nattokinase extract of natto, has been made into capsules and sold as a health product at a high price What mysterious substance is nattokinase? Natto is the product of soybean fermentation "In southern China, natto has been made by ourselves Steam the soybeans and cover them with salt When you put them in the right time, you will find that the soybeans will not have a taste after they are fermented and sticky Sichuan people fry it with ginger Professor Huang Li, director of the heart and vascular disease center of China Japan Friendship Hospital, introduced his home-made method of Douchi In recent years, natto, as a kind of flavor food, has become popular on the dining table, but it benefits from the publicity of "soluble thrombus" and "lowering blood pressure" which are beneficial to health The traditional practice of natto in Japan is also very simple, "natto is actually the product of fermentation after the soybean is cooked." Yun inadvertently, a member of the scientific squirrel society, a popular science writer and author of the truth of eating, explained that traditional fermentation is carried out in straw The cooked soybean is put into a vessel made of straw while it is hot, and the natto bacteria attached to the straw can be used for natural fermentation "Later, the Japanese isolated the bacteria responsible for turning soybeans into natto, which is customarily called natto bacteria, which is actually a kind of Bacillus subtilis Modern natto production can be carried out with purified and cultured natto bacteria, which makes the production of natto more convenient and controllable " The main components of natto are water 61.8%, crude protein 19.26%, crude fat 8.17%, carbohydrate 6.09%, crude fiber 2.2% ash (content of solid inorganic matter) 1.86% After fermentation, the digestibility and absorption rate of soybean products are generally improved "Not only natto, all bean products are good for health, but fermented bean products are more conducive to the absorption of many beneficial components such as protein and functional protein produced by bacteria." Cloud said unintentionally "Natto is not necessarily unique compared to other fermented bean products The reason why natto has won more attention is that the Japanese have conducted a more in-depth study on it, so there are some scientific data to support the claim of natto's "health function" "The Chinese Nutrition Society's dietary guidelines for residents recommend that each person eat no more than 150 grams of bean products per day I think if someone is willing to add natto to to the daily food intake, there is no harm, and it has nutritional value to the body But be careful " Fan Zhihong, associate professor of the Department of nutrition and food safety and doctor of food science, School of food science, China Agricultural University, said, "soybean protein is insoluble When it is made into natto, it becomes soluble and produces amino acids All kinds of enzymes that do not exist in the raw materials can help digestion and absorption of the gastrointestinal tract due to the production of natto bacteria and related probiotics After fermentation, the utilization rate of protein will be increased, and the rate of hindering digestion and absorption will be reduced " Because of the unique flavor of natto, it will have a little taste of ammonia Fan Zhihong recommends that those who can't accept the taste at the moment can choose to add a little soy sauce, vinegar, sugar, mustard and scallion, and cover the flavor with the flavor In fact, fan Zhihong said that in addition to natto, Douchi, all kinds of fermented bean curd (including stinky tofu), miso (Japanese sauce), Douban sauce, big sauce (northeast or Korean sauce), sweet noodle sauce, soy sauce and vinegar are all fermented condiments There are also mash (sweet rice wine), various flour products, etc Pickles, pickles and Korean pickles that meet safety standards, as well as other fermented beans such as bean juice and tofu, are also fermented foods "When beans are fermented and eaten, they all have the advantages of higher digestibility." Experts remind that natto is still just "ordinary food" in China Although there are many opinions advocating natto's health benefits, the Ministry of health is still cautious about natto, which is regarded as ordinary food management "Natto has a certain eating history in China Natto fermented by Bacillus subtilis should be managed as ordinary food (excerpted from the reply of the Ministry of health to the Beijing Municipal Health Bureau on the request for instructions on "natto" as a common food (jjgz [2002] No 104)) "in an experiment conducted in Japan, volunteers eat 200 grams of natto every day for breakfast to show the effect of hemolytic thrombus For most people, it's a huge amount " Cloud said unintentionally "The benefits of diversity and balance in diet are far greater than the benefits of eating only certain foods." Huang Li said that Japan is a country with a long population life, and the incidence rate of cardiovascular and cerebrovascular diseases is low in this country But this is not just the contribution of natto "The Japanese emphasize that they should eat more than 30 kinds of food a day, and they will work hard on nutrition Although Japan has also claimed that eating natto to reduce weight caused the loss of natto, but soon clarified this similar to Zhang Wuben's mung bean theory " "The protein content of 200 grams of natto is very high, and for some people, the kidney may not be able to bear it." Fan Zhihong said that except for vegetarians, they can eat a little more natto, and if they also eat other proteins at the same time, it is easy to cause protein excess In addition, if it is other fermented bean products, eating more easily leads to sodium exceeding the standard "Foods that have a health-care effect on the body are not suitable for all people They are not necessarily free of side effects and are not necessarily harmless to the body." Nattokinase (NK) is a kind of Bacillus subtilis protein kinase, which is a serine protease produced by Bacillus subtilis during the fermentation of natto Du Xiangge, director of the organic agricultural technology research center of China Agricultural University and professor of the school of Agronomy and Biotechnology of China Agricultural University, said that because the Japanese like natto, their research on natto is also full In the 1980s, a Japanese cardio cerebrovascular expert, Dr Su shiyanghang, discovered the protein, later named nattokinase, which can dissolve fibrin in blood vessels and hemolyze thrombus There are also some experiments found that natto or natto extract can also help hypertension and other symptoms "Natto has a certain health care function, but it's not groundless." But he believes that the thrombus melting experiments of nattokinase are often done in animals or small-scale human experiments, so there are still many problems to be studied "For consumers, how much and how to eat to make a difference? Is it better to eat natto or natto extract or natto kinase capsule than other "health care methods"? These problems need further study They are not allowed to be sold because their functions have been 'validated' like drugs, but because no one has reported that they are harmful to humans " Nattokinase products are only health products After the introduction of nattokinase capsule, nattokinase extract was sold in Japan, some manufacturers in China also began to Produce Nattokinase products, and there are many people buying such products on behalf of them "Nattokinase has a certain effect on anticoagulation, but at present, nattokinase capsule is only a health product, not a drug." Huang Li, a health product review expert from the State Food and drug administration, said, "the publicity of health products can only show that it has the auxiliary treatment effect, not the so-called treatment effect For example, nattokinase products can only be said to have the effect of auxiliary hypotension and hemolytic thrombus, rather than hypotension and hemolytic thrombus " "Some scholars in Japan have studied that nattokinase hemolytic thrombus has certain effect, but if Japan's nattokinase is sold in China, it must be approved by China's State Food and drug administration It has been proved by toxicology and pharmacological experiments that it should be marked with a blue hat, otherwise it is not allowed to be sold in a regular way." Huang Li said Contraindications: no use for gout patients with nephropathy According to the Japanese nutrition and health food association, the daily normal maintenance amount of nattokinase in the healthy or sub-healthy population for the prevention of cardiovascular and cerebrovascular diseases should be 2000 Fu (1-2 capsules / day), the recommended dosage for the patients with cardiovascular and cerebrovascular diseases should be 2000 fu-4000 Fu (1-2 capsules / day), and the recommended dosage for the patients with serious cardiovascular and cerebrovascular diseases should be 4000 fu-6000 Fu (2-3 capsules / day) "Whether to eat and how much to take is only for the high-risk population of cardiovascular and cerebrovascular diseases, but if it is a patient who is taking other drugs, it needs to be very careful." Huang Li said that she does not object to and prohibit people at high risk of cardiovascular and cerebrovascular diseases, such as people with high blood pressure, high blood clotting, do not like sports, smoking and other people to take such products, but if the patient is taking other drugs at the same time, "for example, patients who have installed heart stents should take two anticoagulants a year, such as monitoring blood clotting, taking warfarin (stronger than aspirin) and other antithrombotic drugs If the patients take nattokinase again, they will easily form cerebral embolism Hemagglutination patients take it at the same time, it is easy to produce coagulation, bleeding dangerous situation Therefore, high uric acid and gout patients, kidney disease patients, people with history of thrombus or people after stent operation should not take it, while dyspepsia, people with severe diarrhea and vomiting, people with internal organs bleeding and bleeding, people who use large doses of thrombolytic drugs in treatment are all taboo people of nattokinase.