Nat Neurosci: Whole Genome Analysis of 435,563 Alcoholics: What Is the Biology Behind It?
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Last Update: 2020-07-14
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Source: Internet
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Author: User
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Problem drinking (PAU) is the leading cause of death and disability worldwideAlthough genome-wide association studies have identified PAU's risk genes, the genetic structure of this feature has not yet been fully understoodrecently, researchers conducted PAU proxy phenotypes of 435,563 individuals of European descent, combining alcohol use disorders with problematic drinkingresearchers found 29 separate risk variants, 19 of which were newPAU has a genetic correlation with 138 phenotypes, including substance use and psychocharacteristicsa full phenotynotype multigene risk scoring analysis conducted in a separate biobank sample (BioVU, n - 67,589) confirmed the genetic correlation between PAU and drug use and mental illnessPAU's genetic inheritance is enriched in the brain as well as in the conservative and regulated genomic regionsMendel randomization shows that substance use, mental state, risk-taking behavior, and cognitive performance have causal effects on PAUin short, this large-scale PAU meta-analysis identifies new risk sites and reveals genetic relationships with many other characteristics
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