Nat Neurosci: Tang, etc. reveals the neurobiological mechanisms behind "social care."

!---- What impulses are desired to communicate with unfamiliar hearts? What kind of strength makes it difficult to stop the thoughts of relatives and friends? Once talked high, but confidantist difficult to find; gold fan paper drunk only huang Qi a dream; pulse and see the king not see ... I do not know that "the rule of the moon" in Li Bai may be just a friend silently gently a touch, can eliminate his invitation to the moon on the figure of the lonely ... ... Chinese culture has always regarded hugging and touching as an act of over-intimateness and shying about it, but it is a very ordinary and natural social behavior in Western society.psychology, hugging and touching can quickly bring people closer together, eliminate strangeness, increase intimacy and maintain physical and mental health.a particular hypothesis is that hugging and touching trigger a neuropeptide: oxytocin (Oxytocin, OT) release that makes people feel physically and mentally pleasing and has a sense of trust, but for years it has been difficult to prove from a neuroscience perspective because of the lack of technical means.also attributed to oxytocin is not literally simple, as a neuropeptide that spans various species of vertebrates during the 500 million-year evolutionary process, with multiple functions that regulate lactation production, sexuality, socialization, trust, companionship, motherhood, and anti-anxiety, fear and pain, while OT neurons are hidden in the hypothalamus of two small nuclear groups (room side and on-the-field) in the body to study their discharge activities.to explore this issue, on July 27, 2020, Valery Grinevich of the University of Heidelberg, Germany, and Alexandre Charlet of the University of Strasbourg (together with Dr. Tang Yan, Diego Benusiglio, Arthur Lefevre and Louis Hilfiger) published an article in the Journal of Nature Nature Science, Social Touch S.the researchers chose the socially active female rats as the subjects, avoiding the experimental interference between attack behavior and sexual behavior between males and females.recorded by specific optogenetic markers in combination with the microelectrodes of the body, it was first found that back limb contact did trigger a rapid and rapid explosion of oxytocin-enabled OT neurons, and that there was no significant effect on olfactory vision and auditory stimulation.second, in terms of structure and function, the researchers used in body fiber calcium imaging, microdialysis and septic diaphragm pliers to verify the OT neuron microloops controlled by small cells.went on to delve deeper into the different input sources of two types of OT neurons in the brain, proving that small cell OT has more incoming synapses and unique brain region input sources than large cell OT.finally, the researchers manipulated a small number of small cell OT neurons through genetic pharmacology, successfully activating or inhibiting the activity of all OT neurons, thus artificially regulating the social behavior between female rats, increasing or reducing the time of physical contact.physical contact during socialization effectively induces an increase in OT neuron discharge In anaesthetic state, the back blow-up airpuff can effectively reproduce the increase of OT neuron discharge.fiber-optic imaging in combination with DREADD's specific regulation of body sense stimulates airpuff's response to OT neurons, the left red indicates that the drug activates the small cell after-body population OT is more sensitive to airpuff;green for the control group OT neurons to react to airpuff.this study pioneers the release of body-induced mediated endogenous neuropeptides, and finds specific regulatory target smaller cell OT neurons on the neural loop, providing a theoretical basis for the development of specific and effective neuropeptide release drugs, especially in the treatment of mental illnesses such as autism and post-traumatic stress syndrome.back body stimulation is introduced from the brain stem into ot neurons of the hypothalamus, which simultaneously activate large cell OT neurons, releasing oxytocin to the central and peripheral nervous system, thereby increasing social motivation.this study may be the first time that oxytocin has been used to explain the neural mechanisms of "sea memory confidants, even if they are close to each other", and to remind you that social isolation in the post-new crown era will reduce oxytocin release and cause trauma, so it's important to intervene and have psychotherapy.can't hug a handshake, and patting your back can become a healthy and safe new social etiquette. .