Nat Neurosci: revealing the key role of brain circuits in improving learning and memory

October 12, 2019 / Bio Valley / recently, a research report published in the international journal Nature Neuroscience, scientists from the University of California identified a new type of neural circuit during the formation of the big brain horse body through research, which plays a very important role in goal-based learning and memory Photo source: cc0 public domain The loss of object position memory is one of the main obstacles for Alzheimer's disease patients Alzheimer's disease is one of the most common dementia in the elderly These new findings in the hippocampal circuit mechanism may provide researchers with a new target to help develop new strategies or therapies to effectively reduce or neutralize Alzheimer's disease-related memory impairment According to researcher Xiangmin Xu, our research is to detect the connectivity between different structures through new methods based on virus genetic map, and these new mapping tools can help us identify the new circuits in and between the sea horse body and the cerebral cortex In this paper, Xu et al Used single synaptic rabies retrograde tracking and anterograde tracking technology based on herpes (H129) to establish a new cortical hippocampal circuit, which is related to the subcellular projections of hippocampal CA1 Recently, NIH was obtained by researchers The brain project research fund funded the development of a new H129 virus tracer, which can be widely used as a brain imaging tool by scientists in the field of neuroscience The researchers have revealed the mechanism of hippocampal subcircuits highly related to learning and memory disorders (including Alzheimer's disease, etc.), and the relevant research has found that it can be used to better treat Alzheimer's disease and other neurological disorders, and slow down the progress of patients' diseases, and it is also possible to effectively inhibit the disease at the beginning Original sources: Yanjun sun, suoqin Jin, Xiaoxiao Lin, et al Ca1-projecting subjective neurons facility object – place learning, Nature Neuroscience (2019) Doi: 10.1038/s41593-019-0496-y