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Nat Med: Peripheral immune characteristics of PD-1 block response in patients with classic Hodgkin's lymphoma

 Last Update: 2021-04-16
 Source: Internet
 Author: User

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PD-1 blockade is very effective for classic Hodgkin’s lymphomas (cHLs), which is manifested by frequent increase in the copy number of CD274 (PD-L1) and PDC1LG2 (PD-L2) on chromosome 9p24.

Lymphoma immunity

The study included 56 patients who participated in the CheckMate 205 phase II clinical trial (NCT02181738) and obtained peripheral immune characteristics that are responsive to PD-1 blockade.

Fig.

diagnosis

In summary, these findings emphasize the role of the recently expanded, clonally diverse CD4+ T cells and innate effectors in the efficacy of PD-1 blockade in the treatment of cHL.

Original source:

Fathima Zumla Cader, et al.

ncbi.
nlm.
nih.
gov/32778827/" target="_blank" rel="noopener">A peripheral immune signature of responsiveness to PD -1 blockade in patients with classical Hodgkin lymphoma

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