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Nat Med: Febutinib in the treatment of chronic spontaneous urticaria refractory to H1 antihistamines

 Last Update: 2021-12-02
 Source: Internet
 Author: User

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Chronic spontaneous urticaria (CSU) is characterized by the development of wind masses, angioedema, or both without obvious external causes for more than six weeks

Febutinib is an oral, potent, highly selective, and reversible BTK inhibitor, which may be effective in the treatment of CSU

Recently, a research article was published in the top medical journal Nature Medicine.

The primary endpoint of the study was the change from baseline to week 8 in the urticaria activity score over 7 days (UAS7)

Compared with the placebo group in the 50 mg febutinib treatment group, the 200 mg twice a day and 150 mg febutinib treatment group once a day reached the primary end point, that is, the dose-dependent improvement of UAS7 at week 8

Thus, these results support the potential therapeutic effect of BTK inhibitors in CSU refractory to antihistamines

These results support the potential therapeutic effect of BTK inhibitors in CSU refractory to antihistamines

Original source:

Martin Metz,et al.

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